Search Results

Overview

Uniprot ID	Q96L93
Protein Name	Kinesin-like protein KIF16B
Gene Name	KIF16B
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1232	REMHKTLKLKYAELA
1234	MHKTLKLKYAELAAL

Function

Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development

Protein Sequence

10 MASVKVAVRV 20 RPMNRREKDL 30 EAKFIIQMEK 40 SKTTITNLKI 50 PEGGTGDSGR 60 ERTKTFTYDF 70 SFYSADTKSP 80 DYVSQEMVFK 90 TLGTDVVKSA 100 FEGYNACVFA 110 YGQTGSGKSY 120 TMMGNSGDSG 130 LIPRICEGLF 140 SRINETTRWD 150 EASFRTEVSY 160 LEIYNERVRD 170 LLRRKSSKTF 180 NLRVREHPKE 190 GPYVEDLSKH 200 LVQNYGDVEE 210 LMDAGNINRT 220 TAATGMNDVS 230 SRSHAIFTIK 240 FTQAKFDSEM 250 PCETVSKIHL 260 VDLAGSERAD 270 ATGATGVRLK 280 EGGNINKSLV 290 TLGNVISALA 300 DLSQDAANTL 310 AKKKQVFVPY 320 RDSVLTWLLK 330 DSLGGNSKTI 340 MIATISPADV 350 NYGETLSTLR 360 YANRAKNIIN 370 KPTINEDANV 380 KLIRELRAEI 390 ARLKTLLAQG 400 NQIALLDSPT 410 ALSMEEKLQQ 420 NEARVQELTK 430 EWTNKWNETQ 440 NILKEQTLAL 450 RKEGIGVVLD 460 SELPHLIGID 470 DDLLSTGIIL 480 YHLKEGQTYV 490 GRDDASTEQD 500 IVLHGLDLES 510 EHCIFENIGG 520 TVTLIPLSGS 530 QCSVNGVQIV 540 EATHLNQGAV 550 ILLGRTNMFR 560 FNHPKEAAKL 570 REKRKSGLLS 580 SFSLSMTDLS 590 KSRENLSAVM 600 LYNPGLEFER 610 QQREELEKLE 620 SKRKLIEEME 630 EKQKSDKAEL 640 ERMQQEVETQ 650 RKETEIVQLQ 660 IRKQEESLKR 670 RSFHIENKLK 680 DLLAEKEKFE 690 EERLREQQEI 700 ELQKKRQEEE 710 TFLRVQEELQ 720 RLKELNNNEK 730 AEKFQIFQEL 740 DQLQKEKDEQ 750 YAKLELEKKR 760 LEEQEKEQVM 770 LVAHLEEQLR 780 EKQEMIQLLR 790 RGEVQWVEEE 800 KRDLEGIRES 810 LLRVKEARAG 820 GDEDGEELEK 830 AQLRFFEFKR 840 RQLVKLVNLE 850 KDLVQQKDIL 860 KKEVQEEQEI 870 LECLKCEHDK 880 ESRLLEKHDE 890 SVTDVTEVPQ 900 DFEKIKPVEY 910 RLQYKERQLQ 920 YLLQNHLPTL 930 LEEKQRAFEI 940 LDRGPLSLDN 950 TLYQVEKEME 960 EKEEQLAQYQ 970 ANANQLQKLQ 980 ATFEFTANIA 990 RQEEKVRKKE 1000 KEILESREKQ 1010 QREALERALA 1020 RLERRHSALQ 1030 RHSTLGMEIE 1040 EQRQKLASLN 1050 SGSREQSGLQ 1060 ASLEAEQEAL 1070 EKDQERLEYE 1080 IQQLKQKIYE 1090 VDGVQKDHHG 1100 TLEGKVASSS 1110 LPVSAEKSHL 1120 VPLMDARINA 1130 YIEEEVQRRL 1140 QDLHRVISEG 1150 CSTSADTMKD 1160 NEKLHNGTIQ 1170 RKLKYERMVS 1180 RSLGANPDDL 1190 KDPIKISIPR 1200 YVLCGQGKDA 1210 HFEFEVKITV 1220 LDETWTVFRR 1230 YSRFREMHKT 1240 LKLKYAELAA 1250 LEFPPKKLFG 1260 NKDERVIAER 1270 RSHLEKYLRD 1280 FFSVMLQSAT 1290 SPLHINKVGL 1300 TLSKHTICEF 1310 SPFFKKGVFD YSSHGTG

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005769	early endosome
Cellular Component	GO:0031901	early endosome membrane
Cellular Component	GO:0005768	endosome
Cellular Component	GO:0005871	kinesin complex
Cellular Component	GO:0005874	microtubule
Cellular Component	GO:0005819	spindle
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0008017	microtubule binding
Molecular Function	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
Molecular Function	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
Molecular Function	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding
Molecular Function	GO:0032266	phosphatidylinositol-3-phosphate binding
Molecular Function	GO:0008574	plus-end-directed microtubule motor activity
Biological Process	GO:0045022	early endosome to late endosome transport
Biological Process	GO:0007492	endoderm development
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway
Biological Process	GO:0008543	fibroblast growth factor receptor signaling pathway
Biological Process	GO:0001704	formation of primary germ layer
Biological Process	GO:0006895	Golgi to endosome transport
Biological Process	GO:0032801	receptor catabolic process
Biological Process	GO:0001919	regulation of receptor recycling
Biological Process	GO:0047496	vesicle transport along microtubule

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.