Search Results
Overview
| Uniprot ID | Q96LD4 |
|---|---|
| Protein Name | E3 ubiquitin-protein ligase TRIM47 |
| Gene Name | TRIM47 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 636 | KSCISVLKRR***** |
| 69 | PDGLQLRKNHTLSEL |
Function
E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD
Protein Sequence
10
MDGSGPFSCP
20
ICLEPLREPV
30
TLPCGHNFCL
40
ACLGALWPHR
50
GASGAGGPGG
60
AARCPLCQEP
70
FPDGLQLRKN
80
HTLSELLQLR
90
QGSGPGSGPG
100
PAPALAPEPS
110
APSALPSVPE
120
PSAPCAPEPW
130
PAGEEPVRCD
140
ACPEGAALPA
150
ALSCLSCLAS
160
FCPAHLGPHE
170
RSPALRGHRL
180
VPPLRRLEES
190
LCPRHLRPLE
200
RYCRAERVCL
210
CEACAAQEHR
220
GHELVPLEQE
230
RALQEAEQSK
240
VLSAVEDRMD
250
ELGAGIAQSR
260
RTVALIKSAA
270
VAERERVSRL
280
FADAAAALQG
290
FQTQVLGFIE
300
EGEAAMLGRS
310
QGDLRRQEEQ
320
RSRLSRARQN
330
LSQVPEADSV
340
SFLQELLALR
350
LALEDGCGPG
360
PGPPRELSFT
370
KSSQAVRAVR
380
DMLAVACVNQ
390
WEQLRGPGGN
400
EDGPQKLDSE
410
ADAEPQDLES
420
TNLLESEAPR
430
DYFLKFAYIV
440
DLDSDTADKF
450
LQLFGTKGVK
460
RVLCPINYPL
470
SPTRFTHCEQ
480
VLGEGALDRG
490
TYYWEVEIIE
500
GWVSMGVMAE
510
DFSPQEPYDR
520
GRLGRNAHSC
530
CLQWNGRSFS
540
VWFHGLEAPL
550
PHPFSPTVGV
560
CLEYADRALA
570
FYAVRDGKMS
580
LLRRLKASRP
590
RRGGIPASPI
600
DPFQSRLDSH
610
FAGLFTHRLK
620
PAFFLESVDA
630
HLQIGPLKKS
CISVLKRR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0098794 | postsynapse |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0004842 | ubiquitin-protein transferase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0150052 | regulation of postsynapse assembly |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.