Overview
| Uniprot ID | Q96LI5 |
|---|
| Protein Name | CCR4-NOT transcription complex subunit 6-like |
|---|
| Gene Name | CNOT6L |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 270 |
FSPKSRAKIMSEQER |
Function
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence
Protein Sequence
10
MRLIGMPKEK
20
YDPPDPRRIY
30
TIMSAEEVAN
40
GKKSHWAELE
50
ISGRVRSLST
60
SLWSLTHLTA
70
LHLNDNYLSR
80
IPPDIAKLHN
90
LVYLDLSSNK
100
LRSLPAELGN
110
MVSLRELLLN
120
NNLLRVLPYE
130
LGRLFQLQTL
140
GLKGNPLSQD
150
ILNLYQDPDG
160
TRKLLNFMLD
170
NLAVHPEQLP
180
PRPWITLKER
190
DQILPSASFT
200
VMCYNVLCDK
210
YATRQLYGYC
220
PSWALNWEYR
230
KKGIMEEIVN
240
CDADIISLQE
250
VETEQYFTLF
260
LPALKERGYD
270
GFFSPKSRAK
280
IMSEQERKHV
290
DGCAIFFKTE
300
KFTLVQKHTV
310
EFNQVAMANS
320
DGSEAMLNRV
330
MTKDNIGVAV
340
VLEVHKELFG
350
AGMKPIHAAD
360
KQLLIVANAH
370
MHWDPEYSDV
380
KLIQTMMFVS
390
EVKNILEKAS
400
SRPGSPTADP
410
NSIPLVLCAD
420
LNSLPDSGVV
430
EYLSNGGVAD
440
NHKDFKELRY
450
NECLMNFSCN
460
GKNGSSEGRI
470
THGFQLKSAY
480
ENNLMPYTNY
490
TFDFKGVIDY
500
IFYSKTHMNV
510
LGVLGPLDPQ
520
WLVENNITGC
530
PHPHIPSDHF
540
SLLTQLELHP
550
PLLPLVNGVH
LPNRR
Gene Ontology
| Classification |
GO ID |
Description |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Cellular Component |
GO:0030014 |
CCR4-NOT complex |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0000175 |
3'-5'-RNA exonuclease activity |
| Molecular Function |
GO:0004535 |
poly(A)-specific ribonuclease activity |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0000289 |
nuclear-transcribed mRNA poly(A) tail shortening |
| Biological Process |
GO:0008284 |
positive regulation of cell population proliferation |
| Biological Process |
GO:0010606 |
positive regulation of cytoplasmic mRNA processing body assembly |
| Biological Process |
GO:0006417 |
regulation of translation |
| Biological Process |
GO:0031047 |
regulatory ncRNA-mediated gene silencing |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.