Search Results
Overview
| Uniprot ID | Q96LJ7 |
|---|---|
| Protein Name | Dehydrogenase/reductase SDR family member 1 |
| Gene Name | DHRS1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 172 | VGKAACDKLAADCAH |
Function
NADPH-dependent oxidoreductase which catalyzes the reduction of steroids (estrone, androstene-3,17-dione and cortisone) as well as prostaglandin E1, isatin and xenobiotics in vitro (PubMed:30031147). May have a role in steroid and/or xenobiotic metabolism (PubMed:30031147)
Protein Sequence
10
MAAPMNGQVC
20
VVTGASRGIG
30
RGIALQLCKA
40
GATVYITGRH
50
LDTLRVVAQE
60
AQSLGGQCVP
70
VVCDSSQESE
80
VRSLFEQVDR
90
EQQGRLDVLV
100
NNAYAGVQTI
110
LNTRNKAFWE
120
TPASMWDDIN
130
NVGLRGHYFC
140
SVYGARLMVP
150
AGQGLIVVIS
160
SPGSLQYMFN
170
VPYGVGKAAC
180
DKLAADCAHE
190
LRRHGVSCVS
200
LWPGIVQTEL
210
LKEHMAKEEV
220
LQDPVLKQFK
230
SAFSSAETTE
240
LSGKCVVALA
250
TDPNILSLSG
260
KVLPSCDLAR
270
RYGLRDVDGR
280
PVQDYLSLSS
290
VLSHVSGLGW
300
LASYLPSFLR
310
VPKWIIALYT
SKF
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Molecular Function | GO:0004090 | carbonyl reductase (NADPH) activity |
| Molecular Function | GO:0047881 | estradiol 17-alpha-dehydrogenase [NAD(P)+] activity |
| Molecular Function | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| Molecular Function | GO:0047045 | testosterone dehydrogenase (NADP+) activity |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.