Search Results
Overview
| Uniprot ID | Q96LR5 |
|---|---|
| Protein Name | Ubiquitin-conjugating enzyme E2 E2 |
| Gene Name | UBE2E2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 52 | ISSKTAAKLSTSAKR |
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein
Protein Sequence
10
MSTEAQRVDD
20
SPSTSGGSSD
30
GDQRESVQQE
40
PEREQVQPKK
50
KEGKISSKTA
60
AKLSTSAKRI
70
QKELAEITLD
80
PPPNCSAGPK
90
GDNIYEWRST
100
ILGPPGSVYE
110
GGVFFLDITF
120
SPDYPFKPPK
130
VTFRTRIYHC
140
NINSQGVICL
150
DILKDNWSPA
160
LTISKVLLSI
170
CSLLTDCNPA
180
DPLVGSIATQ
190
YMTNRAEHDR
200
MARQWTKRYA
T
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0042296 | ISG15 transferase activity |
| Molecular Function | GO:0061631 | ubiquitin conjugating enzyme activity |
| Molecular Function | GO:0004842 | ubiquitin-protein transferase activity |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0032020 | ISG15-protein conjugation |
| Biological Process | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle |
| Biological Process | GO:0070979 | protein K11-linked ubiquitination |
| Biological Process | GO:0070936 | protein K48-linked ubiquitination |
| Biological Process | GO:0070534 | protein K63-linked ubiquitination |
| Biological Process | GO:0006513 | protein monoubiquitination |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.