Overview
| Uniprot ID | Q96M02 |
|---|
| Protein Name | (E2-independent) E3 ubiquitin-conjugating enzyme FATS |
|---|
| Gene Name | C10orf90 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 528 |
VKIKECKKSEDPTTP |
Function
Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (By similarity). May have a role in the assembly of primary cilia (Probable)
Protein Sequence
10
MLKLSGEGLR
20
DSYHSRRDQI
30
ALKNLQSDVT
40
EAKSDFTKET
50
LASQNTKMIS
60
SIVISQMIDE
70
NKSRENRASL
80
PLPCAIAQSR
90
AHHAKQSLAN
100
RSGVNIHRAF
110
ALLPGRLGIP
120
APSDERGPEA
130
ELPPKEERPC
140
GGPRRGFASI
150
TITARRVGPP
160
ARALVWGTAG
170
DSLCPKCRAE
180
DTLFQAPPAL
190
ANGAHPGRHQ
200
RSFACTEFSR
210
NSSVVRLKVP
220
EAHTGLCERR
230
KYWVTHADDK
240
ETSFSPDTPL
250
SGKSPLVFSS
260
CVHLRVSQQC
270
PDSIYYVDKS
280
LSVPIEPPQI
290
ASPKMHRSVL
300
SLNLNCSSHR
310
LTADGVDGLV
320
NREPISEALK
330
QELLEGDQDL
340
VGQRWNPGLQ
350
ESHLKETPSL
360
RRVHLGTGAC
370
PWSGSFPLEN
380
TELANVGANQ
390
VTVRKGEKDH
400
TTHCHASDHA
410
NQLSIHIPGW
420
SYRAVHTKVF
430
SGSSKRQQGE
440
VCMTVSAPPV
450
EQKPTRHFLP
460
IGDSSPSDDC
470
LSRDLSEPTE
480
RRHQSFLKPR
490
ILFPGFLCPL
500
QDVCASLQED
510
NGVQIESKFP
520
KGDYTCCDLV
530
VKIKECKKSE
540
DPTTPEPSPA
550
APSPAPRDGA
560
GSPGLSEDCS
570
ESQQTPARSL
580
TLQEALEVRK
590
PQFISRSQER
600
LKKLEHMVQQ
610
RKAQRKEDLR
620
QKQSLLPIRT
630
SKKQFTIPHP
640
LSDNLFKPKE
650
RCISEKEMHM
660
RSKRIYDNLP
670
EVKKKKEEQR
680
KRVILQSNRL
690
RAEVFKKQLL
DQLLQRNAV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0015629 |
actin cytoskeleton |
| Cellular Component |
GO:0005814 |
centriole |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Molecular Function |
GO:0061630 |
ubiquitin protein ligase activity |
| Biological Process |
GO:0000209 |
protein polyubiquitination |
| Biological Process |
GO:0050821 |
protein stabilization |
| Biological Process |
GO:0016567 |
protein ubiquitination |
| Biological Process |
GO:0046599 |
regulation of centriole replication |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.