Search Results
Overview
| Uniprot ID | Q96M29 |
|---|---|
| Protein Name | Tektin-5 |
| Gene Name | TEKT5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 212 | LVHDNVEKNLIREVD |
| 265 | SAQCIDEKCFNLRNT |
| 304 | KFSNDNIKHSQNMRA |
| 389 | MAKEGPLKVAQTRLE |
| 467 | TLCIDKEKCMGMRKT |
| 473 | EKCMGMRKTFPCTPR |
Function
Sperm-specific microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellar axoneme. Forms an extensive interaction network in different conformations that reinforces the helix bundle composed by other tektin proteins (TEKT1 to TEKT4) and MIPs to anchor the tektin bundle onto the tubulin wall of A-tubule of the sperm flagellum
Protein Sequence
10
MEFLGTTQTA
20
SYCGPKKCCG
30
LTSLPAVQAP
40
VIQECYQPYY
50
LPGYRYLNSW
60
RPSLFYKIAN
70
VQTCPDESTS
80
TLRPPTILPT
90
LRSALFSRYS
100
PHDWDQSNQL
110
QVRGAEASRL
120
WASRLTDDSM
130
RLLQDKDQLT
140
HQMQEGTCRN
150
LGQRLSDIGF
160
WKSELSYELD
170
RLLTENQNLE
180
TVKRRLECAA
190
NEVNCPLQVA
200
LECLYHREKR
210
IGIDLVHDNV
220
EKNLIREVDL
230
LKCCQEQMRK
240
LAQRIDIQMR
250
DNRDAQHVLE
260
RDLEDKSSAQ
270
CIDEKCFNLR
280
NTSDCISFFH
290
GMEKIDGTIS
300
VPETWAKFSN
310
DNIKHSQNMR
320
ANSIQLREEA
330
EHLFETLSDQ
340
MWRQFTDTNL
350
AFNARISEVT
360
DVKNKLQTQL
370
AKTLQEIFQA
380
ENTIMLLERS
390
IMAKEGPLKV
400
AQTRLECRTR
410
RPNMELCRDI
420
PQLKLVNEVF
430
TIDDTLQTLK
440
LRLRETQDTL
450
QLLVMTKCRL
460
EHELAIKANT
470
LCIDKEKCMG
480
MRKTFPCTPR
LVGHT
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0160111 | axonemal A tubule inner sheath |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0036126 | sperm flagellum |
| Biological Process | GO:0060271 | cilium assembly |
| Biological Process | GO:0060294 | cilium movement involved in cell motility |
| Biological Process | GO:0030317 | flagellated sperm motility |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.