Search Results
Overview
| Uniprot ID | Q96ME7 |
|---|---|
| Protein Name | Zinc finger protein 512 |
| Gene Name | ZNF512 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 119 | DYREFPQKKHKLYGR |
| 120 | YREFPQKKHKLYGRK |
| 18 | TSGPTTFKQQRSTRI |
| 333 | KEMNLESKSGGRVQR |
| 541 | LVVSASCKEPEQEPV |
Function
Sequence-specific DNA-binding protein that recognizes repetitive and non-consecutive TTC sequences in pericentric repeat and initiates heterochromatin formation through interaction with SUV39H1/2 methyltransferases which catalyze histone H3K9 methylation
Protein Sequence
10
MSSRLGAVPA
20
TSGPTTFKQQ
30
RSTRIVGAKN
40
SRTQCSIKDN
50
SFQYTIPHDD
60
SLSGSSSASS
70
CEPVSDFPAS
80
FRKSTYWMKM
90
RRIKPAATSH
100
VEGSGGVSAK
110
GKRKPRQEED
120
EDYREFPQKK
130
HKLYGRKQRP
140
KTQPNPKSQA
150
RRIRKEPPVY
160
AAGSLEEQWY
170
LEIVDKGSVS
180
CPTCQAVGRK
190
TIEGLKKHME
200
NCKQEMFTCH
210
HCGKQLRSLA
220
GMKYHVMANH
230
NSLPILKAGD
240
EIDEPSERER
250
LRTVLKRLGK
260
LRCMRESCSS
270
SFTSIMGYLY
280
HVRKCGKGAA
290
ELEKMTLKCH
300
HCGKPYRSKA
310
GLAYHLRSEH
320
GPISFFPESG
330
QPECLKEMNL
340
ESKSGGRVQR
350
RSAKIAVYHL
360
QELASAELAK
370
EWPKRKVLQD
380
LVPDDRKLKY
390
TRPGLPTFSQ
400
EVLHKWKTDI
410
KKYHRIQCPN
420
QGCEAVYSSV
430
SGLKAHLGSC
440
TLGNFVAGKY
450
KCLLCQKEFV
460
SESGVKYHIN
470
SVHAEDWFVV
480
NPTTTKSFEK
490
LMKIKQRQQE
500
EEKRRQQHRS
510
RRSLRRRQQP
520
GIELPETELS
530
LRVGKDQRRN
540
NEELVVSASC
550
KEPEQEPVPA
560
QFQKVKPPKT
NHKRGRK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005721 | pericentric heterochromatin |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0140719 | constitutive heterochromatin formation |
| Biological Process | GO:0006351 | DNA-templated transcription |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.
[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.