Search Results
Overview
| Uniprot ID | Q96MN9 |
|---|---|
| Protein Name | Zinc finger protein 488 |
| Gene Name | ZNF488 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 109 | FTELPRMKDRQVDAQ |
Function
Transcriptional repressor. Plays a role in oligodendrocyte differentiation, together with OLIG2. Mediates Notch signaling-activated formation of oligodendrocyte precursors. Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury
Protein Sequence
10
MPEWPPCLSV
20
APALVITMAA
30
GKGAPLSPSA
40
ENRWRLSEPE
50
LGRGCKPVLL
60
EKTNRLGPEA
70
AVGRAGRDVG
80
SAELALLVAP
90
GKPRPGKPLP
100
PKTRGEQRQS
110
AFTELPRMKD
120
RQVDAQAQER
130
EHDDPTGQPG
140
APQLTQNIPR
150
GPAGSKVFSV
160
WPSGARSEQR
170
SAFSKPTKRP
180
AERPELTSVF
190
PAGESADALG
200
ELSGLLNTTD
210
LACWGRLSTP
220
KLLVGDLWNL
230
QALPQNAPLC
240
STFLGAPTLW
250
LEHTQAQVPP
260
PSSSSTTSWA
270
LLPPTLTSLG
280
LSTQNWCAKC
290
NLSFRLTSDL
300
VFHMRSHHKK
310
EHAGPDPHSQ
320
KRREEALACP
330
VCQEHFRERH
340
HLSRHMTSHS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0014003 | oligodendrocyte development |
| Biological Process | GO:0031643 | positive regulation of myelination |
| Biological Process | GO:0048714 | positive regulation of oligodendrocyte differentiation |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.