Overview
| Uniprot ID | Q96MT8 |
|---|
| Protein Name | Centrosomal protein of 63 kDa |
|---|
| Gene Name | CEP63 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 470 |
LDQLESLKLENRHLS |
Function
Required for normal spindle assembly (PubMed:21406398, PubMed:21983783, PubMed:26297806, PubMed:35793002). Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:21983783, PubMed:26297806). Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response (PubMed:21406398). Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398). Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination (PubMed:35989368)
Protein Sequence
10
MEALLEGIQN
20
RGHGGGFLTS
30
CEAELQELMK
40
QIDIMVAHKK
50
SEWEGRTHAL
60
ETCLKIREQE
70
LKSLRSQLDV
80
THKEVGMLHQ
90
QVEEHEKIKQ
100
EMTMEYKQEL
110
KKLHEELCIL
120
KRSYEKLQKK
130
QMREFRGNTK
140
NHREDRSEIE
150
RLTAKIEEFR
160
QKSLDWEKQR
170
LIYQQQVSSL
180
EAQRKALAEQ
190
SEIIQAQLVN
200
RKQKLESVEL
210
SSQSEIQHLS
220
SKLERANDTI
230
CANELEIERL
240
TMRVNDLVGT
250
SMTVLQEQQQ
260
KEEKLRESEK
270
LLEALQEEKR
280
ELKAALQSQE
290
NLIHEARIQK
300
EKLQEKVKAT
310
NTQHAVEAIR
320
PREESLAEKK
330
YTSQGQGDLD
340
SVLSQLNFTH
350
TSEDLLQAEV
360
TCLEGSLESV
370
SATCKQLSQE
380
LMEKYEELKR
390
MEAHNNEYKA
400
EIKKLKEQIL
410
QGEQSYSSAL
420
EGMKMEISHL
430
TQELHQRDIT
440
IASTKGSSSD
450
MEKRLRAEMQ
460
KAEDKAVEHK
470
EILDQLESLK
480
LENRHLSEMV
490
MKLELGLHEA
500
KEISLADLQE
510
NYIEALNKLV
520
SENQQLQKDL
530
MNTKSQLEIS
540
TQMCKKQNDR
550
IFKPTHSRTT
560
EFKNTEFKPT
570
HGQHRHDGIK
580
TEHYKTDLHS
590
PRGQASDSIN
600
PMSRVLSPLS
610
PQISPCSSTR
620
SLTSYSLCKT
630
HSLPSALDTN
640
EANFSDTMSE
650
SMNDQEEFIS
660
SCSLPVSPLG
670
SIATRFLEEE
680
ELRSHHILER
690
LDAHIEELKR
700
ESEKTVRQFT
ALK
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0051301 |
cell division |
| Cellular Component |
GO:0034451 |
centriolar satellite |
| Cellular Component |
GO:0005814 |
centriole |
| Cellular Component |
GO:0005813 |
centrosome |
| Cellular Component |
GO:0036064 |
ciliary basal body |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0000922 |
spindle pole |
| Molecular Function |
GO:0060090 |
molecular adaptor activity |
| Biological Process |
GO:0007099 |
centriole replication |
| Biological Process |
GO:0098535 |
de novo centriole assembly involved in multi-ciliated epithelial cell differentiation |
| Biological Process |
GO:0000077 |
DNA damage checkpoint signaling |
| Biological Process |
GO:0045824 |
negative regulation of innate immune response |
| Biological Process |
GO:1900045 |
negative regulation of protein K63-linked ubiquitination |
| Biological Process |
GO:0050821 |
protein stabilization |
| Biological Process |
GO:0042770 |
signal transduction in response to DNA damage |
| Biological Process |
GO:0051225 |
spindle assembly |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.