Overview
| Uniprot ID | Q96N11 |
|---|
| Protein Name | Integrator complex subunit 15 |
|---|
| Gene Name | INTS15 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 273 |
HVSNKVTKDPGVGMD |
Function
Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:36920904, PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:38570683). INTS15 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386). Within the integrator complex, INTS15 is required to bridge different integrator modules (PubMed:36920904)
Protein Sequence
10
MSDIRHSLLR
20
RDALSAAKEV
30
LYHLDIYFSS
40
QLQSAPLPIV
50
DKGPVELLEE
60
FVFQVPKERS
70
AQPKRLNSLQ
80
ELQLLEIMCN
90
YFQEQTKDSV
100
RQIIFSSLFS
110
PQGNKADDSR
120
MSLLGKLVSM
130
AVAVCRIPVL
140
ECAASWLQRT
150
PVVYCVRLAK
160
ALVDDYCCLV
170
PGSIQTLKQI
180
FSASPRFCCQ
190
FITSVTALYD
200
LSSDDLIPPM
210
DLLEMIVTWI
220
FEDPRLILIT
230
FLNTPIAANL
240
PIGFLELTPL
250
VGLIRWCVKA
260
PLAYKRKKKP
270
PLSNGHVSNK
280
VTKDPGVGMD
290
RDSHLLYSKL
300
HLSVLQVLMT
310
LQLHLTEKNL
320
YGRLGLILFD
330
HMVPLVEEIN
340
RLADELNPLN
350
ASQEIELSLD
360
RLAQALQVAM
370
ASGALLCTRD
380
DLRTLCSRLP
390
HNNLLQLVIS
400
GPVQQSPHAA
410
LPPGFYPHIH
420
TPPLGYGAVP
430
AHPAAHPALP
440
THPGHTFISG
VTFPFRPIR
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005694 |
chromosome |
| Cellular Component |
GO:0160232 |
INTAC complex |
| Cellular Component |
GO:0032039 |
integrator complex |
| Cellular Component |
GO:0005634 |
nucleus |
| Biological Process |
GO:0034243 |
regulation of transcription elongation by RNA polymerase II |
| Biological Process |
GO:0160240 |
RNA polymerase II transcription initiation surveillance |
| Biological Process |
GO:0016180 |
snRNA processing |
Reference
[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.