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Overview

Uniprot IDQ96N64
Protein NamePWWP domain-containing protein 2A
Gene NamePWWP2A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
324 PRQVLCDKCKNSVVA
363 ESVTTVNKKLKTDHK
364 SVTTVNKKLKTDHKV
370 KKLKTDHKVDGKNQN
387 QKRNAVVKVSNIAHS
400 HSRGRVVKVSAQANT
409 SAQANTSKAQLSTKK
421 TKKVLQSKNMDHAKA
501 LEKMRSGKMAPKPQS

Function

Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:30327463). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (PubMed:30228260, PubMed:30327463). Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (By similarity). Essential for proper mitosis progression (PubMed:28645917)

Protein Sequence

10 MAAVAAEAAA 20 TAASPGEGGA 30 GEAEPEMEPI 40 PGSEAGTDPL 50 PVTATEASVP 60 DGETDGQQSA 70 PQADEPPLPP 80 PPPPPGELAR 90 SPEAVGPELE 100 AEEKLSVRVA 110 ESAAAAPQGG 120 PELPPSPASP 130 PEQPPAPEER 140 EEPPLPQPVA 150 PALVPPAGGD 160 STVSQLIPGS 170 EVRVTLDHII 180 EDALVVSFRF 190 GEKLFSGVLM 200 DLSKRFGPHG 210 IPVTVFPKRE 220 YKDKPEAMPL 230 QSNTFQEGTE 240 VKCEANGAVP 250 DDPSPVPHPE 260 LSLAESLWTS 270 KPPPLFHEGA 280 PYPPPLFIRD 290 TYNQSIPQPP 300 PRKIKRPKRK 310 MYREEPTSIM 320 NAIKLRPRQV 330 LCDKCKNSVV 340 AEKKEIRKGS 350 SATDSSKYED 360 KKRRNESVTT 370 VNKKLKTDHK 380 VDGKNQNESQ 390 KRNAVVKVSN 400 IAHSRGRVVK 410 VSAQANTSKA 420 QLSTKKVLQS 430 KNMDHAKARE 440 VLKIAKEKAQ 450 KKQNETSTSK 460 NAHSKVHFTR 470 RYQNPSSGSL 480 PPRVRLKPQR 490 YRNEENDSSL 500 KTGLEKMRSG 510 KMAPKPQSRC 520 TSTRSAGEAP 530 SENQSPSKGP 540 EEASSEVQDT 550 NEVHVPGDQD 560 EPQTLGKKGS 570 KNNISVYMTL 580 NQKKSDSSSA 590 SVCSIDSTDD 600 LKSSNSECSS 610 SESFDFPPGS 620 MHAPSTSSTS 630 SSSKEEKKLS 640 NSLKMKVFSK 650 NVSKCVTPDG 660 RTICVGDIVW 670 AKIYGFPWWP 680 ARILTITVSR 690 KDNGLLVRQE 700 ARISWFGSPT 710 TSFLALSQLS 720 PFLENFQSRF 730 NKKRKGLYRK 740 AITEAAKAAK 750 QLTPEVRALL TQFET

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0140003 histone H3K36me3 reader activity
Molecular Function GO:0120325 NuRD complex binding
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0032968 positive regulation of transcription elongation by RNA polymerase II
Biological Process GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.