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Overview

Uniprot IDQ96N67
Protein NameDedicator of cytokinesis protein 7
Gene NameDOCK7
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
10 ERRAFAQKISRTVAA
1395 KSKDMRAKLEEAILG
1962 GELHEQFKRKTILTT
21 TVAAEVRKQISGQYS
381 KEKLEKLKSQADQFC
393 QFCQRLGKYRMPFAW

Function

Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (PubMed:16982419). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (PubMed:29467281). Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity)

Protein Sequence

10 MAERRAFAQK 20 ISRTVAAEVR 30 KQISGQYSGS 40 PQLLKNLNIV 50 GNISHHTTVP 60 LTEAVDPVDL 70 EDYLITHPLA 80 VDSGPLRDLI 90 EFPPDDIEVV 100 YSPRDCRTLV 110 SAVPEESEMD 120 PHVRDCIRSY 130 TEDWAIVIRK 140 YHKLGTGFNP 150 NTLDKQKERQ 160 KGLPKQVFES 170 DEAPDGNSYQ 180 DDQDDLKRRS 190 MSIDDTPRGS 200 WACSIFDLKN 210 SLPDALLPNL 220 LDRTPNEEID 230 RQNDDQRKSN 240 RHKELFALHP 250 SPDEEEPIER 260 LSVPDIPKEH 270 FGQRLLVKCL 280 SLKFEIEIEP 290 IFASLALYDV 300 KEKKKISENF 310 YFDLNSEQMK 320 GLLRPHVPPA 330 AITTLARSAI 340 FSITYPSQDV 350 FLVIKLEKVL 360 QQGDIGECAE 370 PYMIFKEADA 380 TKNKEKLEKL 390 KSQADQFCQR 400 LGKYRMPFAW 410 TAIHLMNIVS 420 SAGSLERDST 430 EVEISTGERK 440 GSWSERRNSS 450 IVGRRSLERT 460 TSGDDACNLT 470 SFRPATLTVT 480 NFFKQEGDRL 490 SDEDLYKFLA 500 DMRRPSSVLR 510 RLRPITAQLK 520 IDISPAPENP 530 HYCLTPELLQ 540 VKLYPDSRVR 550 PTREILEFPA 560 RDVYVPNTTY 570 RNLLYIYPQS 580 LNFANRQGSA 590 RNITVKVQFM 600 YGEDPSNAMP 610 VIFGKSSCSE 620 FSKEAYTAVV 630 YHNRSPDFHE 640 EIKVKLPATL 650 TDHHHLLFTF 660 YHVSCQQKQN 670 TPLETPVGYT 680 WIPMLQNGRL 690 KTGQFCLPVS 700 LEKPPQAYSV 710 LSPEVPLPGM 720 KWVDNHKGVF 730 NVEVVAVSSI 740 HTQDPYLDKF 750 FALVNALDEH 760 LFPVRIGDMR 770 IMENNLENEL 780 KSSISALNSS 790 QLEPVVRFLH 800 LLLDKLILLV 810 IRPPVIAGQI 820 VNLGQASFEA 830 MASIINRLHK 840 NLEGNHDQHG 850 RNSLLASYIH 860 YVFRLPNTYP 870 NSSSPGPGGL 880 GGSVHYATMA 890 RSAVRPASLN 900 LNRSRSLSNS 910 NPDISGTPTS 920 PDDEVRSIIG 930 SKGLDRSNSW 940 VNTGGPKAAP 950 WGSNPSPSAE 960 STQAMDRSCN 970 RMSSHTETSS 980 FLQTLTGRLP 990 TKKLFHEELA 1000 LQWVVCSGSV 1010 RESALQQAWF 1020 FFELMVKSMV 1030 HHLYFNDKLE 1040 APRKSRFPER 1050 FMDDIAALVS 1060 TIASDIVSRF 1070 QKDTEMVERL 1080 NTSLAFFLND 1090 LLSVMDRGFV 1100 FSLIKSCYKQ 1110 VSSKLYSLPN 1120 PSVLVSLRLD 1130 FLRIICSHEH 1140 YVTLNLPCSL 1150 LTPPASPSPS 1160 VSSATSQSSG 1170 FSTNVQDQKI 1180 ANMFELSVPF 1190 RQQHYLAGLV 1200 LTELAVILDP 1210 DAEGLFGLHK 1220 KVINMVHNLL 1230 SSHDSDPRYS 1240 DPQIKARVAM 1250 LYLPLIGIIM 1260 ETVPQLYDFT 1270 ETHNQRGRPI 1280 CIATDDYESE 1290 SGSMISQTVA 1300 MAIAGTSVPQ 1310 LTRPGSFLLT 1320 STSGRQHTTF 1330 SAESSRSLLI 1340 CLLWVLKNAD 1350 ETVLQKWFTD 1360 LSVLQLNRLL 1370 DLLYLCVSCF 1380 EYKGKKVFER 1390 MNSLTFKKSK 1400 DMRAKLEEAI 1410 LGSIGARQEM 1420 VRRSRGQLGT 1430 YTIASPPERS 1440 PSGSAFGSQE 1450 NLRWRKDMTH 1460 WRQNTEKLDK 1470 SRAEIEHEAL 1480 IDGNLATEAN 1490 LIILDTLEIV 1500 VQTVSVTESK 1510 ESILGGVLKV 1520 LLHSMACNQS 1530 AVYLQHCFAT 1540 QRALVSKFPE 1550 LLFEEETEQC 1560 ADLCLRLLRH 1570 CSSSIGTIRS 1580 HASASLYLLM 1590 RQNFEIGNNF 1600 ARVKMQVTMS 1610 LSSLVGTSQN 1620 FNEEFLRRSL 1630 KTILTYAEED 1640 LELRETTFPD 1650 QVQDLVFNLH 1660 MILSDTVKMK 1670 EHQEDPEMLI 1680 DLMYRIAKGY 1690 QTSPDLRLTW 1700 LQNMAGKHSE 1710 RSNHAEAAQC 1720 LVHSAALVAE 1730 YLSMLEDRKY 1740 LPVGCVTFQN 1750 ISSNVLEESA 1760 VSDDVVSPDE 1770 EGICSGKYFT 1780 ESGLVGLLEQ 1790 AAASFSMAGM 1800 YEAVNEVYKV 1810 LIPIHEANRD 1820 AKKLSTIHGK 1830 LQEAFSKIVH 1840 QSTGWERMFG 1850 TYFRVGFYGT 1860 KFGDLDEQEF 1870 VYKEPAITKL 1880 AEISHRLEGF 1890 YGERFGEDVV 1900 EVIKDSNPVD 1910 KCKLDPNKAY 1920 IQITYVEPYF 1930 DTYEMKDRIT 1940 YFDKNYNLRR 1950 FMYCTPFTLD 1960 GRAHGELHEQ 1970 FKRKTILTTS 1980 HAFPYIKTRV 1990 NVTHKEEIIL 2000 TPIEVAIEDM 2010 QKKTQELAFA 2020 THQDPADPKM 2030 LQMVLQGSVG 2040 TTVNQGPLEV 2050 AQVFLSEIPS 2060 DPKLFRHHNK 2070 LRLCFKDFTK 2080 RCEDALRKNK 2090 SLIGPDQKEY 2100 QRELERNYHR 2110 LKEALQPLIN 2120 RKIPQLYKAV 2130 LPVTCHRDSF 2140 SRMSLRKMDL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0045178 basal part of cell
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0030426 growth cone
Cellular Component GO:0043005 neuron projection
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0007409 axonogenesis
Biological Process GO:0045200 establishment of neuroblast polarity
Biological Process GO:0022027 interkinetic nuclear migration
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0120163 negative regulation of cold-induced thermogenesis
Biological Process GO:0031175 neuron projection development
Biological Process GO:1904754 positive regulation of vascular associated smooth muscle cell migration
Biological Process GO:0016601 Rac protein signal transduction
Biological Process GO:0050767 regulation of neurogenesis
Biological Process GO:0035023 regulation of Rho protein signal transduction
Biological Process GO:0031106 septin ring organization

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.