Search Results

Overview

Uniprot IDQ96NC0
Protein NameZinc finger matrin-type protein 2
Gene NameZMAT2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
102 FLDHINGKKHQRNLG
103 LDHINGKKHQRNLGM
123 RSTLDQVKKRFEVNK
15 KNLDFRRKWDKDEYE
45 GKPVQPVKRELLRHR
61 YKVDLESKLGKTIVI
64 DLESKLGKTIVITKT
8 MASGSGTKNLDFRRK

Function

Involved in pre-mRNA splicing as a component of the spliceosome

Protein Sequence

10 MASGSGTKNL 20 DFRRKWDKDE 30 YEKLAEKRLT 40 EEREKKDGKP 50 VQPVKRELLR 60 HRDYKVDLES 70 KLGKTIVITK 80 TTPQSEMGGY 90 YCNVCDCVVK 100 DSINFLDHIN 110 GKKHQRNLGM 120 SMRVERSTLD 130 QVKKRFEVNK 140 KKMEEKQKDY 150 DFEERMKELR 160 EEEEKAKAYK 170 KEKQKEKKRR 180 AEEDLTFEED 190 DEMAAVMGFS GFGSTKKSY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0071005 U2-type precatalytic spliceosome
Cellular Component GO:0046540 U4/U6 x U5 tri-snRNP complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0000398 mRNA splicing, via spliceosome

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.