Overview
| Uniprot ID | Q96ND0 |
|---|
| Protein Name | Mitochondrial inner membrane scaffold 1 |
|---|
| Gene Name | MIMS1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 214 |
GGTSVTVKYLRSHGY |
Function
Mitochondrial inner membrane protein essential for mitochondrial homeostasis, structural integrity, and cellular metabolism. Regulates mitochondrial translation by modulating protein synthesis of mitochondrial DNA-encoded genes. Plays a critical role in skeletal muscle mass and strength by regulating mitochondrial density, function, and protein synthesis. In brown adipose tissue, regulates mitochondrial cristae remodeling in response to cold stress by interacting with mitochondrial protease YME1L1 and enhancing its proteolytic activity, promoting OMA1 degradation and regulating OPA1 processing. Required for cardiac mitochondrial homeostasis and normal cardiomyocyte contractile function. In skeletal muscle, positively regulates myoblast differentiation by enhancing expression of myogenic factors
Protein Sequence
10
MQWNVPRTVS
20
RLARRTCLEP
30
HNAGLFGHCQ
40
NVKGPLLLYN
50
AESKVVLVQG
60
PQKQWLHLSA
70
AQCVAKERRP
80
LDAHPPQPGV
90
LRHKQGKQHV
100
SFRRVFSSSA
110
TAQGTPEKKE
120
EPDPLQDKSI
130
SLYQRFKKTF
140
RQYGKVLIPV
150
HLITSGVWFG
160
TFYYAALKGV
170
NVVPFLELIG
180
LPDSVVSILK
190
NSQSGNALTA
200
YALFKIATPA
210
RYTVTLGGTS
220
VTVKYLRSHG
230
YMSTPPPVKE
240
YLQDRMEETK
250
ELITEKMEET
260
KDRLTEKLQE
270
TKEKVSFKKK
VE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.