Search Results
Overview
| Uniprot ID | Q96NK8 |
|---|---|
| Protein Name | Neurogenic differentiation factor 6 |
| Gene Name | NEUROD6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 58 | APGEETEKEEEEEDR |
Function
Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene (By similarity)
Protein Sequence
10
MLTLPFDESV
20
VMPESQMCRK
30
FSRECEDQKQ
40
IKKPESFSKQ
50
IVLRGKSIKR
60
APGEETEKEE
70
EEEDREEEDE
80
NGLPRRRGLR
90
KKKTTKLRLE
100
RVKFRRQEAN
110
ARERNRMHGL
120
NDALDNLRKV
130
VPCYSKTQKL
140
SKIETLRLAK
150
NYIWALSEIL
160
RIGKRPDLLT
170
FVQNLCKGLS
180
QPTTNLVAGC
190
LQLNARSFLM
200
GQGGEAAHHT
210
RSPYSTFYPP
220
YHSPELTTPP
230
GHGTLDNSKS
240
MKPYNYCSAY
250
ESFYESTSPE
260
CASPQFEGPL
270
SPPPINYNGI
280
FSLKQEETLD
290
YGKNYNYGMH
300
YCAVPPRGPL
310
GQGAMFRLPT
320
DSHFPYDLHL
330
RSQSLTMQDE
LNAVFHN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0070888 | E-box binding |
| Molecular Function | GO:0046983 | protein dimerization activity |
| Biological Process | GO:0061564 | axon development |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0007423 | sensory organ development |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.