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Overview

Uniprot ID	Q96NU1
Protein Name	Sterile alpha motif domain-containing protein 11
Gene Name	SAMD11
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
434	SARRAPRKGGPGPAS

Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, essential for establishing rod photoreceptor cell identity and function by silencing nonrod gene expression in developing rod photoreceptor cells

Protein Sequence

10 MSKGILQVHP 20 PICDCPGCRI 30 SSPVNRGRLA 40 DKRTVALPAA 50 RNLKKERTPS 60 FSASDGDSDG 70 SGPTCGRRPG 80 LKQEDGPHIR 90 IMKRRVHTHW 100 DVNISFREAS 110 CSQDGNLPTL 120 ISSVHRSRHL 130 VMPEHQSRCE 140 FQRGSLEIGL 150 RPAGDLLGKR 160 LGRSPRISSD 170 CFSEKRARSE 180 SPQEALLLPR 190 ELGPSMAPED 200 HYRRLVSALS 210 EASTFEDPQR 220 LYHLGLPSHG 230 EDPPWHDPPH 240 HLPSHDLLRV 250 RQEVAAAALR 260 GPSGLEAHLP 270 SSTAGQRRKQ 280 GLAQHREGAA 290 PAAAPSFSER 300 ELPQPPPLLS 310 PQNAPHVALG 320 PHLRPPFLGV 330 PSALCQTPGY 340 GFLPPAQAEM 350 FAWQQELLRK 360 QNLARLELPA 370 DLLRQKELES 380 ARPQLLAPET 390 ALRPNDGAEE 400 LQRRGALLVL 410 NHGAAPLLAL 420 PPQGPPGSGP 430 PTPSRDSARR 440 APRKGGPGPA 450 SARPSESKEM 460 TGARLWAQDG 470 SEDEPPKDSD 480 GEDPETAAVG 490 CRGPTPGQAP 500 AGGAGAEGKG 510 LFPGSTLPLG 520 FPYAVSPYFH 530 TGAVGGLSMD 540 GEEAPAPEDV 550 TKWTVDDVCS 560 FVGGLSGCGE 570 YTRVFREQGI 580 DGETLPLLTE 590 EHLLTNMGLK 600 LGPALKIRAQ 610 VARRLGRVFY 620 VASFPVALPL 630 QPPTLRAPER 640 ELGTGEQPLS 650 PTTATSPYGG 660 GHALAGQTSP 670 KQENGTLALL 680 PGAPDPSQPL C

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005634	nucleus
Biological Process	GO:0046548	retinal rod cell development
Cellular Component	GO:0035102	PRC1 complex
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function	GO:0042393	histone binding
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0045892	negative regulation of DNA-templated transcription

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.