Search Results

Overview

Uniprot ID	Q96NW7
Protein Name	Leucine-rich repeat-containing protein 7
Gene Name	LRRC7
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
927	TEIPSPFSPGVPWEY

Function

Adapter protein that is required for correct postsynapse architecture and regulates postsynaptic plasticity through interactions with different partners (PubMed:11729199, PubMed:39256359). Through its interaction with CACNA1C, it enhances trafficking of voltage-dependent L-type calcium channels to the dendritic cell membrane and increases channel postsynaptic clustering, thereby facilitating excitatory calcium signaling (By similarity). It also serves as a scaffold that brings CAMK2A and PPP1CA into close proximity, probably facilitating rapid dephosphorylation of CAMK2A by PPP1CA and influencing CAMK2A-mediated regulation of postsynaptic plasticity (PubMed:39256359). Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term synaptic depression (By similarity)

Protein Sequence

10 MMENLIRGRN 20 PPQYQRSPCK 30 EVRAALRKRP 40 EEELQCLEMT 50 TKRKIIGRLV 60 PCRCFRGEEE 70 IISVLDYSHC 80 SLQQVPKEVF 90 NFERTLEELY 100 LDANQIEELP 110 KQLFNCQALR 120 KLSIPDNDLS 130 NLPTTIASLV 140 NLKELDISKN 150 GVQEFPENIK 160 CCKCLTIIEA 170 SVNPISKLPD 180 GFTQLLNLTQ 190 LYLNDAFLEF 200 LPANFGRLVK 210 LRILELRENH 220 LKTLPKSMHK 230 LAQLERLDLG 240 NNEFGELPEV 250 LDQIQNLREL 260 WMDNNALQVL 270 PGSIGKLKML 280 VYLDMSKNRI 290 ETVDMDISGC 300 EALEDLLLSS 310 NMLQQLPDSI 320 GLLKKLTTLK 330 VDDNQLTMLP 340 NTIGNLSLLE 350 EFDCSCNELE 360 SLPSTIGYLH 370 SLRTLAVDEN 380 FLPELPREIG 390 SCKNVTVMSL 400 RSNKLEFLPE 410 EIGQMQKLRV 420 LNLSDNRLKN 430 LPFSFTKLKE 440 LAALWLSDNQ 450 SKALIPLQTE 460 AHPETKQRVL 470 TNYMFPQQPR 480 GDEDFQSDSD 490 SFNPTLWEEQ 500 RQQRMTVAFE 510 FEDKKEDDEN 520 AGKVKDLSCQ 530 APWERGQRGI 540 TLQPARLSGD 550 CCTPWARCDQ 560 QIQDMPVPQN 570 DPQLAWGCIS 580 GLQQERSMCT 590 PLPVAAQSTT 600 LPSLSGRQVE 610 INLKRYPTPY 620 PEDLKNMVKS 630 VQNLVGKPSH 640 GVRVENSNPT 650 ANTEQTVKEK 660 YEHKWPVAPK 670 EITVEDSFVH 680 PANEMRIGEL 690 HPSLAETPLY 700 PPKLVLLGKD 710 KKESTDESEV 720 DKTHCLNNSV 730 SSGTYSDYSP 740 SQASSGSSNT 750 RVKVGSLQTT 760 AKDAVHNSLW 770 GNRIAPSFPQ 780 PLDSKPLLSQ 790 REAVPPGNIP 800 QRPDRLPMSD 810 TFTDNWTDGS 820 HYDNTGFVAE 830 ETTAENANSN 840 PLLSSKSRST 850 SSHGRRPLIR 860 QDRIVGVPLE 870 LEQSTHRHTP 880 ETEVPPSNPW 890 QNWTRTPSPF 900 EDRTAFPSKL 910 ETTPTTSPLP 920 ERKEHIKEST 930 EIPSPFSPGV 940 PWEYHDSNPN 950 RSLSNVFSQI 960 HCRPESSKGV 970 ISISKSTERL 980 SPLMKDIKSN 990 KFKKSQSIDE 1000 IDIGTYKVYN 1010 IPLENYASGS 1020 DHLGSHERPD 1030 KMLGPEHGMS 1040 SMSRSQSVPM 1050 LDDEMLTYGS 1060 SKGPQQQKAS 1070 MTKKVYQFDQ 1080 SFNPQGSVEV 1090 KAEKRIPPPF 1100 QHNPEYVQQA 1110 SKNIAKDLIS 1120 PRAYRGYPPM 1130 EQMFSFSQPS 1140 VNEDAVVNAQ 1150 FASQGARAGF 1160 LRRADSLVSA 1170 TEMAMFRRVN 1180 EPHELPPTDR 1190 YGRPPYRGGL 1200 DRQSSVTVTE 1210 SQFLKRNGRY 1220 EDEHPSYQEV 1230 KAQAGSFPVK 1240 NLTQRRPLSA 1250 RSYSTESYGA 1260 SQTRPVSARP 1270 TMAALLEKIP 1280 SDYNLGNYGD 1290 KPSDNSDLKT 1300 RPTPVKGEES 1310 CGKMPADWRQ 1320 QLLRHIEARR 1330 LDRNAAYKHN 1340 TVNLGMLPYG 1350 GISAMHAGRS 1360 MTLNLQTKSK 1370 FDHQELPLQK 1380 TPSQQSNILD 1390 NGQEDVSPSG 1400 QWNPYPLGRR 1410 DVPPDTITKK 1420 AGSHIQTLMG 1430 SQSLQHRSRE 1440 QQPYEGNINK 1450 VTIQQFQSPL 1460 PIQIPSSQAT 1470 RGPQPGRCLI 1480 QTKGQRSMDG 1490 YPEQFCVRIE 1500 KNPGLGFSIS 1510 GGISGQGNPF 1520 KPSDKGIFVT 1530 RVQPDGPASN 1540 LLQPGDKILQ 1550 ANGHSFVHME 1560 HEKAVLLLKS 1570 FQNTVDLVIQ RELTV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0043194	axon initial segment
Cellular Component	GO:0016323	basolateral plasma membrane
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0014069	postsynaptic density
Cellular Component	GO:0035580	specific granule lumen
Molecular Function	GO:0019901	protein kinase binding
Biological Process	GO:0098609	cell-cell adhesion
Biological Process	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
Biological Process	GO:0098887	neurotransmitter receptor transport, endosome to postsynaptic membrane
Biological Process	GO:0010976	positive regulation of neuron projection development
Biological Process	GO:0043113	receptor clustering

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.