Search Results

Overview

Uniprot ID	Q96P26
Protein Name	Cytosolic 5'-nucleotidase 1B
Gene Name	NT5C1B
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
357	GPAFRFVKALQYVNA

Function

Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, AMP is the major substrate

Protein Sequence

10 MSQTSLKQKK 20 NEPGMRSSKE 30 SLEAEKRKES 40 DKTGVRLSNQ 50 MRRAVNPNHS 60 LRCCPFQGHS 70 SCRRCLCAAE 80 GTALGPCHTI 90 RIYIHMCLLW 100 EQGQQITMMR 110 GSQESSLRKT 120 DSRGYLVRSQ 130 WSRISRSPST 140 KAPSIDEPRS 150 RNTSAKLPSS 160 STSSRTPSTS 170 PSLHDSSPPP 180 LSGQPSLQPP 190 ASPQLPRSLD 200 SRPPTPPEPD 210 PGSRRSTKMQ 220 ENPEAWAQGI 230 VREIRQTRDS 240 QPLEYSRTSP 250 TEWKSSSQRR 260 GIYPASTQLD 270 RNSLSEQQQQ 280 QREDEDDYEA 290 AYWASMRSFY 300 EKNPSCSRPW 310 PPKPKNAITI 320 ALSSCALFNM 330 VDGRKIYEQE 340 GLEKYMEYQL 350 TNENVILTPG 360 PAFRFVKALQ 370 YVNARLRDLY 380 PDEQDLFDIV 390 LMTNNHAQVG 400 VRLINSVNHY 410 GLLIDRFCLT 420 GGKDPIGYLK 430 AYLTNLYIAA 440 DSEKVQEAIQ 450 EGIASATMFD 460 GAKDMAYCDT 470 QLRVAFDGDA 480 VLFSDESEHF 490 TKEHGLDKFF 500 QYDTLCESKP 510 LAQGPLKGFL 520 EDLGRLQKKF 530 YAKNERLLCP 540 IRTYLVTARS 550 AASSGARVLK 560 TLRRWGLEID 570 EALFLAGAPK 580 SPILVKIRPH 590 IFFDDHMFHI 600 EGAQRLGSIA 610 AYGFNKKFSS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0008253	5'-nucleotidase activity
Molecular Function	GO:0000287	magnesium ion binding
Molecular Function	GO:0000166	nucleotide binding
Biological Process	GO:0046085	adenosine metabolic process
Biological Process	GO:0006195	purine nucleotide catabolic process

Reference

[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.