Search Results

Overview

Uniprot IDQ96P47
Protein NameArf-GAP with GTPase, ANK repeat and PH domain-containing protein 3
Gene NameAGAP3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
343 SNIFTSRKGADLDRE

Function

GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway

Protein Sequence

10 MNFQAGGGQS 20 PQQQQQLAGG 30 PPQQFALSNS 40 AAIRAEIQRF 50 ESVHPNIYAI 60 YDLIERIEDL 70 ALQNQIREHV 80 ISIEDSFVNS 90 QEWTLSRSVP 100 ELKVGIVGNL 110 SSGKSALVHR 120 YLTGTYVQEE 130 SPEGGRFKKE 140 IVVDGQSYLL 150 LIRDEGGPPE 160 LQFAAWVDAV 170 VFVFSLEDEI 180 SFQTVYNYFL 190 RLCSFRNASE 200 VPMVLVGTQD 210 AISAANPRVI 220 DDSRARKLST 230 DLKRCTYYET 240 CATYGLNVER 250 VFQDVAQKVV 260 ALRKKQQLAI 270 GPCKSLPNSP 280 SHSAVSAASI 290 PAVHINQATN 300 GGGSAFSDYS 310 SSVPSTPSIS 320 QRELRIETIA 330 ASSTPTPIRK 340 QSKRRSNIFT 350 SRKGADLDRE 360 KKAAECKVDS 370 IGSGRAIPIK 380 QGILLKRSGK 390 SLNKEWKKKY 400 VTLCDNGLLT 410 YHPSLHDYMQ 420 NIHGKEIDLL 430 RTTVKVPGKR 440 LPRATPATAP 450 GTSPRANGLS 460 VERSNTQLGG 470 GTGAPHSASS 480 ASLHSERPLS 490 SSAWAGPRPE 500 GLHQRSCSVS 510 SADQWSEATT 520 SLPPGMQHPA 530 SGPAEVLSSS 540 PKLDPPPSPH 550 SNRKKHRRKK 560 STGTPRPDGP 570 SSATEEAEES 580 FEFVVVSLTG 590 QTWHFEASTA 600 EERELWVQSV 610 QAQILASLQG 620 CRSAKDKTRL 630 GNQNAALAVQ 640 AVRTVRGNSF 650 CIDCDAPNPD 660 WASLNLGALM 670 CIECSGIHRH 680 LGAHLSRVRS 690 LDLDDWPPEL 700 LAVMTAMGNA 710 LANSVWEGAL 720 GGYSKPGPDA 730 CREEKERWIR 740 AKYEQKLFLA 750 PLPSSDVPLG 760 QQLLRAVVED 770 DLRLLVMLLA 780 HGSKEEVNET 790 YGDGDGRTAL 800 HLSSAMANVV 810 FTQLLIWYGV 820 DVRSRDARGL 830 TPLAYARRAG 840 SQECADILIQ 850 HGCPGEGCGL 860 APTPNREPAN 870 GTNPSAELHR SPSLL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071944 cell periphery
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005634 nucleus
Cellular Component GO:0014069 postsynaptic density
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0031593 polyubiquitin modification-dependent protein binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0034614 cellular response to reactive oxygen species
Biological Process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.