Search Results

Overview

Uniprot IDQ96P70
Protein NameImportin-9
Gene NameIPO9
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
903 RTRSKSAKNPERWTN

Function

Nuclear transport receptor that mediates nuclear import of proteins, such as histones, proteasome and actin (PubMed:11823430, PubMed:30855230, PubMed:34711951). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the import of pre-assembled proteasomes into the nucleus; AKIRIN2 acts as a molecular bridge between IPO9 and the proteasome complex (PubMed:11823430, PubMed:34711951). Mediates the nuclear import of histones H2A, H2B, H4 and H4 (PubMed:11823430, PubMed:30855230). In addition to nuclear import, also acts as a chaperone for histones by preventing inappropriate non-nucleosomal interactions (PubMed:30855230). Mediates the nuclear import of actin (By similarity)

Protein Sequence

10 MAAAAAAGAA 20 SGLPGPVAQG 30 LKEALVDTLT 40 GILSPVQEVR 50 AAAEEQIKVL 60 EVTEEFGVHL 70 AELTVDPQGA 80 LAIRQLASVI 90 LKQYVETHWC 100 AQSEKFRPPE 110 TTERAKIVIR 120 ELLPNGLRES 130 ISKVRSSVAY 140 AVSAIAHWDW 150 PEAWPQLFNL 160 LMEMLVSGDL 170 NAVHGAMRVL 180 TEFTREVTDT 190 QMPLVAPVIL 200 PEMYKIFTMA 210 EVYGIRTRSR 220 AVEIFTTCAH 230 MICNMEELEK 240 GAAKVLIFPV 250 VQQFTEAFVQ 260 ALQIPDGPTS 270 DSGFKMEVLK 280 AVTALVKNFP 290 KHMVSSMQQI 300 LPIVWNTLTE 310 SAAFYVRTEV 320 NYTEEVEDPV 330 DSDGEVLGFE 340 NLVFSIFEFV 350 HALLENSKFK 360 STVKKALPEL 370 IYYIILYMQI 380 TEEQIKVWTA 390 NPQQFVEDED 400 DDTFSYTVRI 410 AAQDLLLAVA 420 TDFQNESAAA 430 LAAAATRHLQ 440 EAEQTKNSGT 450 EHWWKIHEAC 460 MLALGSVKAI 470 ITDSVKNGRI 480 HFDMHGFLTN 490 VILADLNLSV 500 SPFLLGRALW 510 AASRFTVAMS 520 PELIQQFLQA 530 TVSGLHETQP 540 PSVRISAVRA 550 IWGYCDQLKV 560 SESTHVLQPF 570 LPSILDGLIH 580 LAAQFSSEVL 590 NLVMETLCIV 600 CTVDPEFTAS 610 MESKICPFTI 620 AIFLKYSNDP 630 VVASLAQDIF 640 KELSQIEACQ 650 GPMQMRLIPT 660 LVSIMQAPAD 670 KIPAGLCATA 680 IDILTTVVRN 690 TKPPLSQLLI 700 CQAFPAVAQC 710 TLHTDDNATM 720 QNGGECLRAY 730 VSVTLEQVAQ 740 WHDEQGHNGL 750 WYVMQVVSQL 760 LDPRTSEFTA 770 AFVGRLVSTL 780 ISKAGRELGE 790 NLDQILRAIL 800 SKMQQAETLS 810 VMQSLIMVFA 820 HLVHTQLEPL 830 LEFLCSLPGP 840 TGKPALEFVM 850 AEWTSRQHLF 860 YGQYEGKVSS 870 VALCKLLQHG 880 INADDKRLQD 890 IRVKGEEIYS 900 MDEGIRTRSK 910 SAKNPERWTN 920 IPLLVKILKL 930 IINELSNVME 940 ANAARQATPA 950 EWSQDDSNDM 960 WEDQEEEEEE 970 EEDGLAGQLL 980 SDILATSKYE 990 EDYYEDDEED 1000 DPDALKDPLY 1010 QIDLQAYLTD 1020 FLCQFAQQPC 1030 YIMFSGHLND 1040 NERRVLQTIG I

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005635 nuclear envelope
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0042393 histone binding
Molecular Function GO:0140713 histone chaperone activity
Molecular Function GO:0061608 nuclear import signal receptor activity
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0031144 proteasome localization
Biological Process GO:0006606 protein import into nucleus

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.