Search Results

Overview

Uniprot IDQ96PC5
Protein NameMelanoma inhibitory activity protein 2
Gene NameMIA2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1007 NEMKLHRKLTVEENY
803 AEAKMTFKIFQMNEE
868 AEQVLNDKESHIKTL
929 KKLIHAAKLNASLKT

Function

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179)

Protein Sequence

10 MAKFGVHRIL 20 LLAISLTKCL 30 ESTKLLADLK 40 KCGDLECEAL 50 INRVSAMRDY 60 RGPDCRYLNF 70 TKGEEISVYV 80 KLAGEREDLW 90 AGSKGKEFGY 100 FPRDAVQIEE 110 VFISEEIQMS 120 TKESDFLCLL 130 GVSYTFDNED 140 SELNGDYGEN 150 IYPYEEDKDE 160 KSSIYESDFQ 170 IEPGFYATYE 180 STLFEDQVPA 190 LEAPEDIGST 200 SESKDWEEVV 210 VESMEQDRIP 220 EVHVPPSSAV 230 SGVKEWFGLG 240 GEQAEEKAFE 250 SVIEPVQESS 260 FRSRKIAVED 270 ENDLEELNNG 280 EPQTEHQQES 290 ESEIDSVPKT 300 QSELASESEH 310 IPKPQSTGWF 320 GGGFTSYLGF 330 GDEDTGLELI 340 AEESNPPLQD 350 FPNSISSDKE 360 ATVPCTEILT 370 EKKDTITNDS 380 LSLKPSWFDF 390 GFAILGFAYA 400 KEDKIMLDDR 410 KNEEDGGADE 420 HEHPLTSELD 430 PEKEQEIETI 440 KIIETEDQID 450 KKPVSEKTDE 460 SDTIPYLKKF 470 LYNFDNPWNF 480 QNIPKETELP 490 FPKQILDQNN 500 VIENEETGEF 510 SIDNYPTDNT 520 KVMIFKSSYS 530 LSDMVSNIEL 540 PTRIHEEVYF 550 EPSSSKDSDE 560 NSKPSVDTEG 570 PALVEIDRSV 580 ENTLLNSQMV 590 STDNSLSSQN 600 YISQKEDASE 610 FQILKYLFQI 620 DVYDFMNSAF 630 SPIVILTERV 640 VAALPEGMRP 650 DSNLYGFPWE 660 LVICAAVVGF 670 FAVLFFLWRS 680 FRSVRSRLYV 690 GREKKLALML 700 SGLIEEKSKL 710 LEKFSLVQKE 720 YEGYEVESSL 730 KDASFEKEAT 740 EAQSLEATCE 750 KLNRSNSELE 760 DEILCLEKEL 770 KEEKSKHSEQ 780 DELMADISKR 790 IQSLEDESKS 800 LKSQVAEAKM 810 TFKIFQMNEE 820 RLKIAIKDAL 830 NENSQLQESQ 840 KQLLQEAEVW 850 KEQVSELNKQ 860 KVTFEDSKVH 870 AEQVLNDKES 880 HIKTLTERLL 890 KMKDWAAMLG 900 EDITDDDNLE 910 LEMNSESENG 920 AYLDNPPKGA 930 LKKLIHAAKL 940 NASLKTLEGE 950 RNQIYIQLSE 960 VDKTKEELTE 970 HIKNLQTEQA 980 SLQSENTHFE 990 NENQKLQQKL 1000 KVMTELYQEN 1010 EMKLHRKLTV 1020 EENYRLEKEE 1030 KLSKVDEKIS 1040 HATEELETYR 1050 KRAKDLEEEL 1060 ERTIHSYQGQ 1070 IISHEKKAHD 1080 NWLAARNAER 1090 NLNDLRKENA 1100 HNRQKLTETE 1110 LKFELLEKDP 1120 YALDVPNTAF 1130 GREHSPYGPS 1140 PLGWPSSETR 1150 AFLSPPTLLE 1160 GPLRLSPLLP 1170 GGGGRGSRGP 1180 GNPLDHQITN 1190 ERGESSCDRL 1200 TDPHRAPSDT 1210 GSLSPPWDQD 1220 RRMMFPPPGQ 1230 SYPDSALPPQ 1240 RQDRFCSNSG 1250 RLSGPAELRS 1260 FNMPSLDKMD 1270 GSMPSEMESS 1280 RNDTKDDLGN 1290 LNVPDSSLPA 1300 ENEATGPGFV 1310 PPPLAPIRGP 1320 LFPVDARGPF 1330 LRRGPPFPPP 1340 PPGAMFGASR 1350 DYFPPGDFPG 1360 PPPAPFAMRN 1370 VYPPRGFPPY 1380 LPPRPGFFPP 1390 PPHSEGRSEF 1400 PSGLIPPSNE 1410 PATEHPEPQQ ET

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0070971 endoplasmic reticulum exit site
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0016020 membrane
Molecular Function GO:0038024 cargo receptor activity
Molecular Function GO:0008047 enzyme activator activity
Biological Process GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
Biological Process GO:0042953 lipoprotein transport
Biological Process GO:0032527 protein exit from endoplasmic reticulum
Biological Process GO:0070973 protein localization to endoplasmic reticulum exit site
Biological Process GO:0009306 protein secretion
Biological Process GO:0035459 vesicle cargo loading

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.