Overview
| Uniprot ID | Q96PD4 |
|---|
| Protein Name | Interleukin-17F |
|---|
| Gene Name | IL17F |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 13 |
LHGPAMVKYLLLSIL |
Function
Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:21350122). IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:11574464, PubMed:11591732, PubMed:11591768, PubMed:17911633, PubMed:18684971, PubMed:21350122, PubMed:28827714). IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation (By similarity). As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:32187518). Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi. Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes (By similarity)
Protein Sequence
10
MTVKTLHGPA
20
MVKYLLLSIL
30
GLAFLSEAAA
40
RKIPKVGHTF
50
FQKPESCPPV
60
PGGSMKLDIG
70
IINENQRVSM
80
SRNIESRSTS
90
PWNYTVTWDP
100
NRYPSEVVQA
110
QCRNLGCINA
120
QGKEDISMNS
130
VPIQQETLVV
140
RRKHQGCSVS
150
FQLEKVLVTV
160
GCTCVTPVIH
HVQ
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005576 |
extracellular region |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0005125 |
cytokine activity |
| Molecular Function |
GO:0019955 |
cytokine binding |
| Molecular Function |
GO:0005126 |
cytokine receptor binding |
| Molecular Function |
GO:0046982 |
protein heterodimerization activity |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Biological Process |
GO:0051216 |
cartilage development |
| Biological Process |
GO:0050829 |
defense response to Gram-negative bacterium |
| Biological Process |
GO:0050830 |
defense response to Gram-positive bacterium |
| Biological Process |
GO:0006954 |
inflammatory response |
| Biological Process |
GO:0045087 |
innate immune response |
| Biological Process |
GO:0097400 |
interleukin-17-mediated signaling pathway |
| Biological Process |
GO:0016525 |
negative regulation of angiogenesis |
| Biological Process |
GO:0002225 |
positive regulation of antimicrobial peptide production |
| Biological Process |
GO:2000340 |
positive regulation of chemokine (C-X-C motif) ligand 1 production |
| Biological Process |
GO:0001819 |
positive regulation of cytokine production |
| Biological Process |
GO:0032755 |
positive regulation of interleukin-6 production |
| Biological Process |
GO:0032761 |
positive regulation of lymphotoxin A production |
| Biological Process |
GO:0070534 |
protein K63-linked ubiquitination |
| Biological Process |
GO:0032645 |
regulation of granulocyte macrophage colony-stimulating factor production |
| Biological Process |
GO:0032663 |
regulation of interleukin-2 production |
| Biological Process |
GO:0032675 |
regulation of interleukin-6 production |
| Biological Process |
GO:0032677 |
regulation of interleukin-8 production |
| Biological Process |
GO:0017015 |
regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process |
GO:0072538 |
T-helper 17 type immune response |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.