Search Results
Overview
| Uniprot ID | Q96PF2 |
|---|---|
| Protein Name | Testis-specific serine/threonine-protein kinase 2 |
| Gene Name | TSSK2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 246 | KNLTCECKDLIYRML |
Function
Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body
Protein Sequence
10
MDDATVLRKK
20
GYIVGINLGK
30
GSYAKVKSAY
40
SERLKFNVAV
50
KIIDRKKTPT
60
DFVERFLPRE
70
MDILATVNHG
80
SIIKTYEIFE
90
TSDGRIYIIM
100
ELGVQGDLLE
110
FIKCQGALHE
120
DVARKMFRQL
130
SSAVKYCHDL
140
DIVHRDLKCE
150
NLLLDKDFNI
160
KLSDFGFSKR
170
CLRDSNGRII
180
LSKTFCGSAA
190
YAAPEVLQSI
200
PYQPKVYDIW
210
SLGVILYIMV
220
CGSMPYDDSD
230
IRKMLRIQKE
240
HRVDFPRSKN
250
LTCECKDLIY
260
RMLQPDVSQR
270
LHIDEILSHS
280
WLQPPKPKAT
290
SSASFKREGE
300
GKYRAECKLD
310
TKTGLRPDHR
320
PDHKLGAKTQ
330
HRLLVVPENE
340
NRMEDRLAET
350
SRAKDHHISG
AEVGKAST
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0005814 | centriole |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Biological Process | GO:0046777 | protein autophosphorylation |
| Biological Process | GO:0007286 | spermatid development |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.