Overview
| Uniprot ID | Q96PM9 |
|---|
| Protein Name | Zinc finger protein 385A |
|---|
| Gene Name | ZNF385A |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 68 |
TFGGPLLKTKRPVIS |
Function
RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation
Protein Sequence
10
MILGSLSRAG
20
PLPLLRQPPI
30
MQPPLDLKQI
40
LPFPLEPAPT
50
LGLFSNYSTM
60
DPVQKAVLSH
70
TFGGPLLKTK
80
RPVISCNICQ
90
IRFNSQSQAE
100
AHYKGNRHAR
110
RVKGIEAAKT
120
RGREPGVREP
130
GDPAPPGSTP
140
TNGDGVAPRP
150
VSMENGLGPA
160
PGSPEKQPGS
170
PSPPSIPETG
180
QGVTKGEGGT
190
PAPASLPGGS
200
KEEEEKAKRL
210
LYCALCKVAV
220
NSLSQLEAHN
230
KGTKHKTILE
240
ARSGLGPIKA
250
YPRLGPPTPG
260
EPEAPAQDRT
270
FHCEICNVKV
280
NSEVQLKQHI
290
SSRRHRDGVA
300
GKPNPLLSRH
310
KKSRGAGELA
320
GTLTFSKELP
330
KSLAGGLLPS
340
PLAVAAVMAA
350
AAGSPLSLRP
360
APAAPLLQGP
370
PITHPLLHPA
380
PGPIRTAHGP
ILFSPY
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0030425 |
dendrite |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0003677 |
DNA binding |
| Molecular Function |
GO:0003730 |
mRNA 3'-UTR binding |
| Molecular Function |
GO:0002039 |
p53 binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006915 |
apoptotic process |
| Biological Process |
GO:0006974 |
DNA damage response |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0035855 |
megakaryocyte development |
| Biological Process |
GO:0010609 |
mRNA localization resulting in post-transcriptional regulation of gene expression |
| Biological Process |
GO:1902166 |
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| Biological Process |
GO:0043517 |
positive regulation of DNA damage response, signal transduction by p53 class mediator |
| Biological Process |
GO:0045600 |
positive regulation of fat cell differentiation |
| Biological Process |
GO:2000765 |
regulation of cytoplasmic translation |
Reference
PMID: N/A