Search Results

Overview

Uniprot IDQ96PN7
Protein NameTranscriptional-regulating factor 1
Gene NameTRERF1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1045 GGTNQVTKARGAIPS
1054 RGAIPSGKQKPGGTQ
134 ASEIRTQKLTSGVLH
646 PKAEEPLKTVQEKKK

Function

Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1

Protein Sequence

10 MGDQQLYKTN 20 HVAHGSENLF 30 YQQPPLGVHS 40 GLNHNYGNAV 50 TGGGMDAPQA 60 SPISPHFPQD 70 TRDGLGLPVG 80 SKNLGQMDTS 90 RQGGWGSHAG 100 PGNHVQLRGN 110 LANSNMMWGA 120 PAQAEPTDGY 130 QYTYSQASEI 140 RTQKLTSGVL 150 HKLDSFTQVF 160 ANQNLRIQVN 170 NMAQVLHTQS 180 AVMDGAPDSA 190 LRQLLSQKPM 200 EPPAPAIPSR 210 YQQVPQQPHP 220 GFTGGLSKPA 230 LQVGQHPTQG 240 HLYYDYQQPL 250 AQVPVQGGQP 260 LQAPQMLSQH 270 MQQMQQHQYY 280 PPQQQQQAGQ 290 QRISMQEIQT 300 QPQQIRPSQP 310 QPPPQQQQPQ 320 QLQLQQRQGS 330 MQIPQYYQPQ 340 PMMQHLQEQQ 350 QQQMHLQPPS 360 YHRDPHQYTP 370 EQAHTVQLIP 380 LGSMSQYYYQ 390 EPQQPYSHPL 400 YQQSHLSQHQ 410 QREDSQLKTY 420 SSDRQAQAML 430 SSHGDLGPPD 440 TGMGDPASSD 450 LTRVSSTLPH 460 RPLLSPSGIH 470 LNNMGPQHQQ 480 LSPSAMWPQM 490 HLPDGRAQPG 500 SPESSGQPKG 510 AFGEQFDAKN 520 KLTCSICLKE 530 FKNLPALNGH 540 MRSHGGMRAS 550 PNLKQEEGEK 560 VLPPQPQPPL 570 PPPPPPPPPP 580 QLPPEAESLT 590 PMVMPVSVPV 600 KLLPPKPSSQ 610 GFTNSTVAAP 620 SARDKPASSM 630 SDDEMPVLEI 640 PRKHQPSVPK 650 AEEPLKTVQE 660 KKKFRHRPEP 670 LFIPPPPSYN 680 PNPAASYSGA 690 TLYQSQLRSP 700 RVLGDHLLLD 710 PTHELPPYTP 720 PPMLSPVRQG 730 SGLFSNVLIS 740 GHGPGAHPQL 750 PLTPLTPTPR 760 VLLCRSNSID 770 GSNVTVTPGP 780 GEQTVDVEPR 790 INIGLRFQAE 800 IPELQDISAL 810 AQDTHKATLV 820 WKPWPELENH 830 DLQQRVENLL 840 NLCCSSALPG 850 GGTNSEFALH 860 SLFEAKGDVM 870 VALEMLLLRK 880 PVRLKCHPLA 890 NYHYAGSDKW 900 TSLERKLFNK 910 ALATYSKDFI 920 FVQKMVKSKT 930 VAQCVEYYYT 940 WKKIMRLGRK 950 HRTRLAEIID 960 DCVTSEEEEE 970 LEEEEEEDPE 980 EDRKSTKEEE 990 SEVPKSPEPP 1000 PVPVLAPTEG 1010 PPLQALGQPS 1020 GSFICEMPNC 1030 GAVFSSRQAL 1040 NGHARIHGGT 1050 NQVTKARGAI 1060 PSGKQKPGGT 1070 QSGYCSVKSS 1080 PSHSTTSGET 1090 DPTTIFPCKE 1100 CGKVFFKIKS 1110 RNAHMKTHRQ 1120 QEEQQRQKAQ 1130 KAAFAAEMAA 1140 TIERTTGPVG 1150 APGLLPLDQL 1160 SLIKPIKDVD 1170 ILDDDVVQQL 1180 GGVMEEAEVV 1190 DTDLLLDDQD 1200 SVLLQGDAEL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000118 histone deacetylase complex
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005667 transcription regulator complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0033142 nuclear progesterone receptor binding
Molecular Function GO:0003713 transcription coactivator activity
Molecular Function GO:0001223 transcription coactivator binding
Molecular Function GO:0003714 transcription corepressor activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0071393 cellular response to progesterone stimulus
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0050847 progesterone receptor signaling pathway
Biological Process GO:0006357 regulation of transcription by RNA polymerase II

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.