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Overview

Uniprot IDQ96PU9
Protein NameCiliary microtubule associated protein 1A
Gene NameCIMAP1A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
196 DVRVTKFKAPQYTMA
81 PKILRTGKDLGPAYS

Function

Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail

Protein Sequence

10 MTEEVWMGTW 20 RPHRPRGPIM 30 ALYSSPGPKY 40 LIPPTTGFMK 50 HTPTKLRAPA 60 YSFRGAPMLL 70 AENCSPGPRY 80 NVNPKILRTG 90 KDLGPAYSIL 100 GRYQTKTMLT 110 PGPGDYFPEK 120 STKYVFDSAP 130 SHSISARTKA 140 FRVDSTPGPA 150 AYMLPMVMGP 160 NTVGKASQPS 170 FSIKGRSKLG 180 GFSDDLHKTP 190 GPAAYRQTDV 200 RVTKFKAPQY 210 TMAARVEPPG 220 DKTLKPGPGA 230 HSPEKVTLTK 240 PCAPVVTFGI 250 KHSDYMTPLL VDVE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0001520 outer dense fiber
Biological Process GO:0030154 cell differentiation
Biological Process GO:0030317 flagellated sperm motility
Biological Process GO:0007283 spermatogenesis

Reference

[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.