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Overview

Uniprot IDQ96PV0
Protein NameRas/Rap GTPase-activating protein SynGAP
Gene NameSYNGAP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1111 PRQQSLSKEGSIGGS

Function

Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity)

Protein Sequence

10 MSRSRASIHR 20 GSIPAMSYAP 30 FRDVRGPSMH 40 RTQYVHSPYD 50 RPGWNPRFCI 60 ISGNQLLMLD 70 EDEIHPLLIR 80 DRRSESSRNK 90 LLRRTVSVPV 100 EGRPHGEHEY 110 HLGRSRRKSV 120 PGGKQYSMEG 130 APAAPFRPSQ 140 GFLSRRLKSS 150 IKRTKSQPKL 160 DRTSSFRQIL 170 PRFRSADHDR 180 ARLMQSFKES 190 HSHESLLSPS 200 SAAEALELNL 210 DEDSIIKPVH 220 SSILGQEFCF 230 EVTTSSGTKC 240 FACRSAAERD 250 KWIENLQRAV 260 KPNKDNSRRV 270 DNVLKLWIIE 280 ARELPPKKRY 290 YCELCLDDML 300 YARTTSKPRS 310 ASGDTVFWGE 320 HFEFNNLPAV 330 RALRLHLYRD 340 SDKKRKKDKA 350 GYVGLVTVPV 360 ATLAGRHFTE 370 QWYPVTLPTG 380 SGGSGGMGSG 390 GGGGSGGGSG 400 GKGKGGCPAV 410 RLKARYQTMS 420 ILPMELYKEF 430 AEYVTNHYRM 440 LCAVLEPALN 450 VKGKEEVASA 460 LVHILQSTGK 470 AKDFLSDMAM 480 SEVDRFMERE 490 HLIFRENTLA 500 TKAIEEYMRL 510 IGQKYLKDAI 520 GEFIRALYES 530 EENCEVDPIK 540 CTASSLAEHQ 550 ANLRMCCELA 560 LCKVVNSHCV 570 FPRELKEVFA 580 SWRLRCAERG 590 REDIADRLIS 600 ASLFLRFLCP 610 AIMSPSLFGL 620 MQEYPDEQTS 630 RTLTLIAKVI 640 QNLANFSKFT 650 SKEDFLGFMN 660 EFLELEWGSM 670 QQFLYEISNL 680 DTLTNSSSFE 690 GYIDLGRELS 700 TLHALLWEVL 710 PQLSKEALLK 720 LGPLPRLLND 730 ISTALRNPNI 740 QRQPSRQSER 750 PRPQPVVLRG 760 PSAEMQGYMM 770 RDLNSSIDLQ 780 SFMARGLNSS 790 MDMARLPSPT 800 KEKPPPPPPG 810 GGKDLFYVSR 820 PPLARSSPAY 830 CTSSSDITEP 840 EQKMLSVNKS 850 VSMLDLQGDG 860 PGGRLNSSSV 870 SNLAAVGDLL 880 HSSQASLTAA 890 LGLRPAPAGR 900 LSQGSGSSIT 910 AAGMRLSQMG 920 VTTDGVPAQQ 930 LRIPLSFQNP 940 LFHMAADGPG 950 PPGGHGGGGG 960 HGPPSSHHHH 970 HHHHHHRGGE 980 PPGDTFAPFH 990 GYSKSEDLSS 1000 GVPKPPAASI 1010 LHSHSYSDEF 1020 GPSGTDFTRR 1030 QLSLQDNLQH 1040 MLSPPQITIG 1050 PQRPAPSGPG 1060 GGSGGGSGGG 1070 GGGQPPPLQR 1080 GKSQQLTVSA 1090 AQKPRPSSGN 1100 LLQSPEPSYG 1110 PARPRQQSLS 1120 KEGSIGGSGG 1130 SGGGGGGGLK 1140 PSITKQHSQT 1150 PSTLNPTMPA 1160 SERTVAWVSN 1170 MPHLSADIES 1180 AHIEREEYKL 1190 KEYSKSMDES 1200 RLDRVKEYEE 1210 EIHSLKERLH 1220 MSNRKLEEYE 1230 RRLLSQEEQT 1240 SKILMQYQAR 1250 LEQSEKRLRQ 1260 QQAEKDSQIK 1270 SIIGRLMLVE 1280 EELRRDHPAM 1290 AEPLPEPKKR 1300 LLDAQERQLP 1310 PLGPTNPRVT 1320 LAPPWNGLAP 1330 PAPPPPPRLQ 1340 ITENGEFRNT ADH

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0043198 dendritic shaft
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0016020 membrane
Cellular Component GO:0014069 postsynaptic density
Molecular Function GO:0005096 GTPase activator activity
Molecular Function GO:0017124 SH3 domain binding
Biological Process GO:0098880 maintenance of postsynaptic specialization structure
Biological Process GO:0046580 negative regulation of Ras protein signal transduction
Biological Process GO:1902531 regulation of intracellular signal transduction
Biological Process GO:0048167 regulation of synaptic plasticity

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.