Search Results
Overview
| Uniprot ID | Q96Q89 |
|---|---|
| Protein Name | Kinesin-like protein KIF20B |
| Gene Name | KIF20B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 511 | LDSNSNSKILNVKRA |
Function
Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436)
Protein Sequence
10
MESNFNQEGV
20
PRPSYVFSAD
30
PIARPSEINF
40
DGIKLDLSHE
50
FSLVAPNTEA
60
NSFESKDYLQ
70
VCLRIRPFTQ
80
SEKELESEGC
90
VHILDSQTVV
100
LKEPQCILGR
110
LSEKSSGQMA
120
QKFSFSKVFG
130
PATTQKEFFQ
140
GCIMQPVKDL
150
LKGQSRLIFT
160
YGLTNSGKTY
170
TFQGTEENIG
180
ILPRTLNVLF
190
DSLQERLYTK
200
MNLKPHRSRE
210
YLRLSSEQEK
220
EEIASKSALL
230
RQIKEVTVHN
240
DSDDTLYGSL
250
TNSLNISEFE
260
ESIKDYEQAN
270
LNMANSIKFS
280
VWVSFFEIYN
290
EYIYDLFVPV
300
SSKFQKRKML
310
RLSQDVKGYS
320
FIKDLQWIQV
330
SDSKEAYRLL
340
KLGIKHQSVA
350
FTKLNNASSR
360
SHSIFTVKIL
370
QIEDSEMSRV
380
IRVSELSLCD
390
LAGSERTMKT
400
QNEGERLRET
410
GNINTSLLTL
420
GKCINVLKNS
430
EKSKFQQHVP
440
FRESKLTHYF
450
QSFFNGKGKI
460
CMIVNISQCY
470
LAYDETLNVL
480
KFSAIAQKVC
490
VPDTLNSSQE
500
KLFGPVKSSQ
510
DVSLDSNSNS
520
KILNVKRATI
530
SWENSLEDLM
540
EDEDLVEELE
550
NAEETQNVET
560
KLLDEDLDKT
570
LEENKAFISH
580
EEKRKLLDLI
590
EDLKKKLINE
600
KKEKLTLEFK
610
IREEVTQEFT
620
QYWAQREADF
630
KETLLQEREI
640
LEENAERRLA
650
IFKDLVGKCD
660
TREEAAKDIC
670
ATKVETEETH
680
NYVGFEDIID
690
SLQDNVADIK
700
KQAEIAHLYI
710
ASLPDPQEAT
720
ACLELKFNQI
730
KAELAKTKGE
740
LIKTKEELKK
750
RENESDSLIQ
760
ELETSNKKII
770
TQNQRIKELI
780
NIIDQKEDTI
790
NEFQNLKSHM
800
ENTFKCNDKA
810
DTSSLIINNK
820
LICNETVEVP
830
KDSKSKICSE
840
RKRVNENELQ
850
QDEPPAKKGS
860
IHVSSAITED
870
QKKSEEVRPN
880
IAEIEDIRVL
890
QENNEGLRAF
900
LLTIENELKN
910
EKEEKAELNK
920
QIVHFQQELS
930
LSEKKNLTLS
940
KEVQQIQSNY
950
DIAIAELHVQ
960
KSKNQEQEEK
970
IMKLSNEIET
980
ATRSITNNVS
990
QIKLMHTKID
1000
ELRTLDSVSQ
1010
ISNIDLLNLR
1020
DLSNGSEEDN
1030
LPNTQLDLLG
1040
NDYLVSKQVK
1050
EYRIQEPNRE
1060
NSFHSSIEAI
1070
WEECKEIVKA
1080
SSKKSHQIEE
1090
LEQQIEKLQA
1100
EVKGYKDENN
1110
RLKEKEHKNQ
1120
DDLLKEKETL
1130
IQQLKEELQE
1140
KNVTLDVQIQ
1150
HVVEGKRALS
1160
ELTQGVTCYK
1170
AKIKELETIL
1180
ETQKVECSHS
1190
AKLEQDILEK
1200
ESIILKLERN
1210
LKEFQEHLQD
1220
SVKNTKDLNV
1230
KELKLKEEIT
1240
QLTNNLQDMK
1250
HLLQLKEEEE
1260
ETNRQETEKL
1270
KEELSASSAR
1280
TQNLKADLQR
1290
KEEDYADLKE
1300
KLTDAKKQIK
1310
QVQKEVSVMR
1320
DEDKLLRIKI
1330
NELEKKKNQC
1340
SQELDMKQRT
1350
IQQLKEQLNN
1360
QKVEEAIQQY
1370
ERACKDLNVK
1380
EKIIEDMRMT
1390
LEEQEQTQVE
1400
QDQVLEAKLE
1410
EVERLATELE
1420
KWKEKCNDLE
1430
TKNNQRSNKE
1440
HENNTDVLGK
1450
LTNLQDELQE
1460
SEQKYNADRK
1470
KWLEEKMMLI
1480
TQAKEAENIR
1490
NKEMKKYAED
1500
RERFFKQQNE
1510
MEILTAQLTE
1520
KDSDLQKWRE
1530
ERDQLVAALE
1540
IQLKALISSN
1550
VQKDNEIEQL
1560
KRIISETSKI
1570
ETQIMDIKPK
1580
RISSADPDKL
1590
QTEPLSTSFE
1600
ISRNKIEDGS
1610
VVLDSCEVST
1620
ENDQSTRFPK
1630
PELEIQFTPL
1640
QPNKMAVKHP
1650
GCTTPVTVKI
1660
PKARKRKSNE
1670
MEEDLVKCEN
1680
KKNATPRTNL
1690
KFPISDDRNS
1700
SVKKEQKVAI
1710
RPSSKKTYSL
1720
RSQASIIGVN
1730
LATKKKEGTL
1740
QKFGDFLQHS
1750
PSILQSKAKK
1760
IIETMSSSKL
1770
SNVEASKENV
1780
SQPKRAKRKL
1790
YTSEISSPID
1800
ISGQVILMDQ
1810
KMKESDHQII
1820
KRRLRTKTAK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0036064 | ciliary basal body |
| Cellular Component | GO:0070938 | contractile ring |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0005871 | kinesin complex |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:1990023 | mitotic spindle midzone |
| Cellular Component | GO:0097431 | mitotic spindle pole |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0051233 | spindle midzone |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0003777 | microtubule motor activity |
| Molecular Function | GO:0008574 | plus-end-directed microtubule motor activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0050699 | WW domain binding |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0007018 | microtubule-based movement |
| Biological Process | GO:0048812 | neuron projection morphogenesis |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0032467 | positive regulation of cytokinesis |
| Biological Process | GO:0090316 | positive regulation of intracellular protein transport |
| Biological Process | GO:1903438 | positive regulation of mitotic cytokinetic process |
| Biological Process | GO:2001224 | positive regulation of neuron migration |
| Biological Process | GO:0035372 | protein localization to microtubule |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:2000114 | regulation of establishment of cell polarity |
| Biological Process | GO:0007088 | regulation of mitotic nuclear division |
Reference
PMID: N/A