Search Results
Overview
| Uniprot ID | Q96RE7 |
|---|---|
| Protein Name | Nucleus accumbens-associated protein 1 |
| Gene Name | NACC1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 183 | VQCMPVAKRLWDSGQ |
Function
Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines
Protein Sequence
10
MAQTLQMEIP
20
NFGNSILECL
30
NEQRLQGLYC
40
DVSVVVKGHA
50
FKAHRAVLAA
60
SSSYFRDLFN
70
NSRSAVVELP
80
AAVQPQSFQQ
90
ILSFCYTGRL
100
SMNVGDQFLL
110
MYTAGFLQIQ
120
EIMEKGTEFF
130
LKVSSPSCDS
140
QGLHAEEAPS
150
SEPQSPVAQT
160
SGWPACSTPL
170
PLVSRVKTEQ
180
QESDSVQCMP
190
VAKRLWDSGQ
200
KEAGGGGNGS
210
RKMAKFSTPD
220
LAANRPHQPP
230
PPQQAPVVAA
240
AQPAVAAGAG
250
QPAGGVAAAG
260
GVVSGPSTSE
270
RTSPGTSSAY
280
TSDSPGSYHN
290
EEDEEEDGGE
300
EGMDEQYRQI
310
CNMYTMYSMM
320
NVGQTAEKVE
330
ALPEQVAPES
340
RNRIRVRQDL
350
ASLPAELINQ
360
IGNRCHPKLY
370
DEGDPSEKLE
380
LVTGTNVYIT
390
RAQLMNCHVS
400
AGTRHKVLLR
410
RLLASFFDRN
420
TLANSCGTGI
430
RSSTNDPRRK
440
PLDSRVLHAV
450
KYYCQNFAPN
460
FKESEMNAIA
470
ADMCTNARRV
480
VRKSWMPKVK
490
VLKAEDDAYT
500
TFISETGKIE
510
PDMMGVEHGF
520
ETASHEGEAG
PSAEALQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.