Search Results

Overview

Uniprot ID	Q96RK0
Protein Name	Protein capicua homolog
Gene Name	CIC
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
1181	PDWKWCNKDRKKSSS

Function

Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development

Protein Sequence

10 MKPMKKACTG 20 LSGPGSGSKS 30 PPATRAKALR 40 RRGAGEGDKP 50 EEEDDEAQQP 60 QPQSGPEEAE 70 EGEEEEAERG 80 PGAEGPPLEL 90 HPGDPAPGPA 100 EDPKGDGEAG 110 RWEPSLSRKT 120 ATFKSRAPKK 130 KYVEEHGAGS 140 SGVAGAPEER 150 VRTPEEASGL 160 GVPPRPPTST 170 RSSSTDTASE 180 HSADLEDEPA 190 EACGPGPWPP 200 GSTSGSYDLR 210 QLRSQRVLAR 220 RGDGLFLPAV 230 VRQVRRSQDL 240 GVQFPGDRAL 250 TFYEGVPGAG 260 VDVVLDATPP 270 PGALVVGTAV 280 CTCVEPGVAA 290 YREGVVVEVA 300 TKPAAYKVRL 310 SPGPSSQPGL 320 PGSLPQPPQP 330 LHREPEEAVW 340 VARSSLRLLR 350 PPWEPETMLR 360 KPPTGPEEEQ 370 AEPGATLPPC 380 PAALDPKQPE 390 DAEVSKISFG 400 GNLGTHCEEG 410 EEKHPPALGT 420 PALLPLPPPQ 430 LLSPPPKSPA 440 FVGPGRPGEQ 450 PSPCQEGSQG 460 GSRSSSVASL 470 EKGTAPAARA 480 RTPLTAAQQK 490 YKKGDVVCTP 500 SGIRKKFNGK 510 QWRRLCSRDG 520 CMKESQRRGY 530 CSRHLSMRTK 540 EMEGLADSGP 550 GGAGRPAAVA 560 AREGSTEFDW 570 GDETSRDSEA 580 SSVAARGDSR 590 PRLVAPADLS 600 RFEFDECEAA 610 VMLVSLGSSR 620 SGTPSFSPVS 630 TQSPFSPAPS 640 PSPSPLFGFR 650 PANFSPINAS 660 PVIQRTAVRS 670 RHLSASTPKA 680 GVLTPPDLGP 690 HPPPPAPRER 700 HSSGILPTFQ 710 TNLTFTVPIS 720 PGRRKTELLP 730 HPGALGAPGA 740 GGGGAAPDFP 750 KSDSLDSGVD 760 SVSHTPTPST 770 PAGFRAVSPA 780 VPFSRSRQPS 790 PLLLLPPPAG 800 LTSDPGPSVR 810 RVPAVQRDSP 820 VIVRNPDVPL 830 PSKFPGEVGT 840 AGEVRAGGPG 850 RGCRETPVPP 860 GVASGKPGLP 870 PPLPAPVPIT 880 VPPAAPTAVA 890 QPMPAFGLAS 900 SPFQPVAFHP 910 SPAALLPVLV 920 PSSYTSHPAP 930 KKEVIMGRPG 940 TVWTNVEPRS 950 VAVFPWHSLV 960 PFLAPSQPDP 970 SVQPSEAQQP 980 ASHPVASNQS 990 KEPAESAAVA 1000 HERPPGGTGS 1010 ADPERPPGAT 1020 CPESPGPGPP 1030 HPLGVVESGK 1040 GPPPTTEEEA 1050 SGPPGEPRLD 1060 SETESDHDDA 1070 FLSIMSPEIQ 1080 LPLPPGKRRT 1090 QSLSALPKER 1100 DSSSEKDGRS 1110 PNKREKDHIR 1120 RPMNAFMIFS 1130 KRHRALVHQR 1140 HPNQDNRTVS 1150 KILGEWWYAL 1160 GPKEKQKYHD 1170 LAFQVKEAHF 1180 KAHPDWKWCN 1190 KDRKKSSSEA 1200 KPTSLGLAGG 1210 HKETRERSMS 1220 ETGTAAAPGV 1230 SSELLSVAAQ 1240 TLLSSDTKAP 1250 GSSSCGAERL 1260 HTVGGPGSAR 1270 PRAFSHSGVH 1280 SLDGGEVDSQ 1290 ALQELTQMVS 1300 GPASYSGPKP 1310 STQYGAPGPF 1320 AAPGEGGALA 1330 ATGRPPLLPT 1340 RASRSQRAAS 1350 EDMTSDEERM 1360 VICEEEGDDD 1370 VIADDGFGTT 1380 DIDLKCKERV 1390 TDSESGDSSG 1400 EDPEGNKGFG 1410 RKVFSPVIRS 1420 SFTHCRPPLD 1430 PEPPGPPDPP 1440 VAFGKGYGSA 1450 PSSSASSPAS 1460 SSASAATSFS 1470 LGSGTFKAQE 1480 SGQGSTAGPL 1490 RPPPPGAGGP 1500 ATPSKATRFL 1510 PMDPATFRRK 1520 RPESVGGLEP 1530 PGPSVIAAPP 1540 SGGGNILQTL 1550 VLPPNKEEQE 1560 GGGARVPSAP 1570 APSLAYGAPA 1580 APLSRPAATM 1590 VTNVVRPVSS 1600 TPVPIASKPF 1610 PTSGRAEASP 1620 NDTAGARTEM 1630 GTGSRVPGGS 1640 PLGVSLVYSD 1650 KKSAAATSPA 1660 PHLVAGPLLG 1670 TVGKAPATVT 1680 NLLVGTPGYG 1690 APAPPAVQFI 1700 AQGAPGGGTT 1710 AGSGAGAGSG 1720 PNGPVPLGIL 1730 QPGALGKAGG 1740 ITQVQYILPT 1750 LPQQLQVAPA 1760 PAPAPGTKAA 1770 APSGPAPTTS 1780 IRFTLPPGTS 1790 TNGKVLAATA 1800 PTPGIPILQS 1810 VPSAPPPKAQ 1820 SVSPVQAPPP 1830 GGSAQLLPGK 1840 VLVPLAAPSM 1850 SVRGGGAGQP 1860 LPLVSPPFSV 1870 PVQNGAQPPS 1880 KIIQLTPVPV 1890 STPSGLVPPL 1900 SPATLPGPTS 1910 QPQKVLLPSS 1920 TRITYVQSAG 1930 GHALPLGTSP 1940 ASSQAGTVTS 1950 YGPTSSVALG 1960 FTSLGPSGPA 1970 FVQPLLSAGQ 1980 APLLAPGQVG 1990 VSPVPSPQLP 2000 PACAAPGGPV 2010 ITAFYSGSPA 2020 PTSSAPLAQP 2030 SQAPPSLVYT 2040 VATSTTPPAA 2050 TILPKGPPAP 2060 ATATPAPTSP 2070 FPSATAGSMT 2080 YSLVAPKAQR 2090 PSPKAPQKVK 2100 AAIASIPVGS 2110 FEAGASGRPG 2120 PAPRQPLEPG 2130 PVREPTAPES 2140 ELEGQPTPPA 2150 PPPLPETWTP 2160 TARSSPPLPP 2170 PAEERTSAKG 2180 PETMASKFPS 2190 SSSDWRVPGQ 2200 GLENRGEPPT 2210 PPSPAPAPAV 2220 APGGSSESSS 2230 GRAAGDTPER 2240 KEAAGTGKKV 2250 KVRPPPLKKT 2260 FDSVDNRVLS 2270 EVDFEERFAE 2280 LPEFRPEEVL 2290 PSPTLQSLAT 2300 SPRAILGSYR 2310 KKRKNSTDLD 2320 SAPEDPTSPK 2330 RKMRRRSSCS 2340 SEPNTPKSAK 2350 CEGDIFTFDR 2360 TGTEAEDVLG 2370 ELEYDKVPYS 2380 SLRRTLDQRR 2390 ALVMQLFQDH 2400 GFFPSAQATA 2410 AFQARYADIF 2420 PSKVCLQLKI 2430 REVRQKIMQA 2440 ATPTEQPPGA 2450 EAPLPVPPPT 2460 GTAAAPAPTP 2470 SPAGGPDPTS 2480 PSSDSGTAQA 2490 APPLPPPPES 2500 GPGQPGWEGA 2510 PQPSPPPPGP STAATGR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0032991	protein-containing complex
Molecular Function	GO:0003682	chromatin binding
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding
Biological Process	GO:0007420	brain development
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0007612	learning
Biological Process	GO:0007613	memory
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0035176	social behavior

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.