Search Results

Overview

Uniprot IDQ96RP9
Protein NameElongation factor G, mitochondrial
Gene NameGFM1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
212 MGLEGNFKGIVDLIE
541 PFDFTHKKQSGGAGQ

Function

Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis

Protein Sequence

10 MRLLGAAAVA 20 ALGRGRAPAS 30 LGWQRKQVNW 40 KACRWSSSGV 50 IPNEKIRNIG 60 ISAHIDSGKT 70 TLTERVLYYT 80 GRIAKMHEVK 90 GKDGVGAVMD 100 SMELERQRGI 110 TIQSAATYTM 120 WKDVNINIID 130 TPGHVDFTIE 140 VERALRVLDG 150 AVLVLCAVGG 160 VQCQTMTVNR 170 QMKRYNVPFL 180 TFINKLDRMG 190 SNPARALQQM 200 RSKLNHNAAF 210 MQIPMGLEGN 220 FKGIVDLIEE 230 RAIYFDGDFG 240 QIVRYGEIPA 250 ELRAAATDHR 260 QELIECVANS 270 DEQLGEMFLE 280 EKIPSISDLK 290 LAIRRATLKR 300 SFTPVFLGSA 310 LKNKGVQPLL 320 DAVLEYLPNP 330 SEVQNYAILN 340 KEDDSKEKTK 350 ILMNSSRDNS 360 HPFVGLAFKL 370 EVGRFGQLTY 380 VRSYQGELKK 390 GDTIYNTRTR 400 KKVRLQRLAR 410 MHADMMEDVE 420 EVYAGDICAL 430 FGIDCASGDT 440 FTDKANSGLS 450 MESIHVPDPV 460 ISIAMKPSNK 470 NDLEKFSKGI 480 GRFTREDPTF 490 KVYFDTENKE 500 TVISGMGELH 510 LEIYAQRLER 520 EYGCPCITGK 530 PKVAFRETIT 540 APVPFDFTHK 550 KQSGGAGQYG 560 KVIGVLEPLD 570 PEDYTKLEFS 580 DETFGSNIPK 590 QFVPAVEKGF 600 LDACEKGPLS 610 GHKLSGLRFV 620 LQDGAHHMVD 630 SNEISFIRAG 640 EGALKQALAN 650 ATLCILEPIM 660 AVEVVAPNEF 670 QGQVIAGINR 680 RHGVITGQDG 690 VEDYFTLYAD 700 VPLNDMFGYS 710 TELRSCTEGK 720 GEYTMEYSRY 730 QPCLPSTQED 740 VINKYLEATG 750 QLPVKKGKAK N

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003746 translation elongation factor activity
Biological Process GO:0070125 mitochondrial translational elongation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.