Search Results

Overview

Uniprot IDQ96RT7
Protein NameGamma-tubulin complex component 6
Gene NameTUBGCP6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1642 KLMMWALKDVCFHLK

Function

Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:11694571, PubMed:38305685, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685, PubMed:38609661, PubMed:39321809)

Protein Sequence

10 MASITQLFDD 20 LCEALLPAAK 30 THLGQRSVNR 40 KRAKRSLKKV 50 AYNALFTNLF 60 QDETQQLQPD 70 MSKLPARNKI 80 LMLSFDLRVG 90 GLGPKADRLE 100 ELVEELEAAP 110 CCPLLEVGSV 120 LDLLVQLAGS 130 GPPQVLPRKR 140 DYFLNNKHVG 150 RNVPYSGYDC 160 DDLSVFEMDV 170 QSLISREECL 180 CHSMIQETLQ 190 VMEAAPGTGL 200 PTVGLFSFGD 210 PCGDRFERDT 220 RVSLFGALVH 230 SRTYDMDVRL 240 GLPPVPDNAD 250 LSGLAIKVPP 260 SVDQWEDEGF 270 QSASNLTPDS 280 QSEPSVTPDV 290 DLWEAALTYE 300 ASKRRCWERV 310 GCPPGHREEP 320 YLTEAGRDAF 330 DKFCRLHQGE 340 LQLLAGGVLQ 350 APQPVLVKEC 360 ELVKDVLNVL 370 IGVVSATFSL 380 CQPAQAFVVK 390 RGVHVSGASP 400 ESISSLLSEV 410 AEYGTCYTRL 420 SHFSLQPVLD 430 SLYSKGLVFQ 440 AFTSGLRRYL 450 QYYRACVLST 460 PPTLSLLTIG 470 FLFKKLGRQL 480 RYLAELCGVG 490 AVLPGTCGGG 500 PRAAFPTGVK 510 LLSYLYQEAL 520 HNCSNEHYPV 530 LLSLLKTSCE 540 PYTRFIHDWV 550 YSGVFRDAYG 560 EFMIQVNHEY 570 LSFRDKLYWT 580 HGYVLISKEV 590 EDCVPVFLKH 600 IAHDIYVCGK 610 TINLLKLCCP 620 RHYLCWSDVP 630 VPRISVIFSL 640 EELKEIEKDC 650 AVYVGRMERV 660 ARHSSVSKEE 670 KELRMEIAKQ 680 ELIAHAREAA 690 SRVLSALSDR 700 QMSERMALDA 710 RKREQFQRLK 720 EQFVKDQERR 730 QAARQEELDD 740 DFSYARELRD 750 RERRLKSLEE 760 ELERKARQAL 770 VDHYSKLSAE 780 AARREQKALW 790 RIQRHRLESA 800 RLRFLLEDEK 810 HIQEMLKAVS 820 EAHQPQEPPD 830 VLLSVHPQVT 840 SPGPEHPEGG 850 QGCDSGSAEQ 860 HSPAWDGWNR 870 PGLLTPQPLK 880 PLAVGAGGRG 890 LQQAEGARPF 900 SDSLSIGDFL 910 PVGPGAEPSV 920 QTGMVPLLEV 930 ALQTINLDLP 940 PSAPGEAPAA 950 ASTQPSRPQE 960 YDFSTVLRPA 970 VATSPAPGPL 980 QAAECSLGSS 990 GLQLWEDSCG 1000 KMDACGSASR 1010 ETLLPSHPPR 1020 RAALEEGSSQ 1030 PTERLFGQVS 1040 GGGLPTGDYA 1050 SEIAPTRPRW 1060 NTHGHVSDAS 1070 IRVGENVSDV 1080 APTQPRWNTH 1090 GHVSNASISL 1100 GESVSDVAPT 1110 RPRWNIHGHV 1120 SNASIRVGEN 1130 VSDVAPTRPR 1140 WNTHGHVSNA 1150 SIRVGENVSD 1160 VAPTRPRWNT 1170 HGHVSDASIS 1180 LGESVSDMAP 1190 ARPRWNTHGH 1200 VSDASISLGE 1210 SVSDMAPTRP 1220 RWNTHGHVSD 1230 TSIRVGENVS 1240 DVAPIRSRCN 1250 THGHVSDASI 1260 SLGEPVSDVV 1270 STRPRWNTHV 1280 PIPPPHMVLG 1290 ALSPEAEPNT 1300 PRPQQSPPGH 1310 TSQSALSLGA 1320 QSTVLDCGPR 1330 LPVEVGPSLS 1340 SPSSGCGEGS 1350 ISVGENVSDV 1360 APTQPWWPNT 1370 PGDSVSEELG 1380 PGRSGDTEDL 1390 SPNWPLNSQE 1400 DTAAQSSPGR 1410 GEEAEASAAE 1420 AQGGEQAYLA 1430 GLAGQYHLER 1440 YPDSYESMSE 1450 PPIAHLLRPV 1460 LPRAFAFPVD 1470 PQVQSAADET 1480 AVQLSELLTL 1490 PVLMKRSITA 1500 PLAAHISLVN 1510 KAAVDYFFVE 1520 LHLEAHYEAL 1530 RHFLLMEDGE 1540 FAQSLSDLLF 1550 EKLGAGQTPG 1560 ELLNPLVLNS 1570 VLSKALQCSL 1580 HGDTPHASNL 1590 SLALKYLPEV 1600 FAPNAPDVLS 1610 CLELRYKVDW 1620 PLNIVITEGC 1630 VSKYSGVFSF 1640 LLQLKLMMWA 1650 LKDVCFHLKR 1660 TALLSHMAGS 1670 VQFRQLQLFK 1680 HEMQHFVKVI 1690 QGYIANQILH 1700 VTWCEFRARL 1710 ATVGDLEEIQ 1720 RAHAEYLHKA 1730 VFRGLLTEKA 1740 APVMNVIHSI 1750 FSLVLKFRSQ 1760 LISQAWGPPG 1770 GPRGAEHPNF 1780 ALMQQSYNTF 1790 KYYSHFLFKV 1800 VTKLVNRGYQ 1810 PHLEDFLLRI NFNNYYQDA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0000930 gamma-tubulin complex
Cellular Component GO:0000931 gamma-tubulin ring complex
Cellular Component GO:0016020 membrane
Cellular Component GO:0005874 microtubule
Cellular Component GO:0000922 spindle pole
Molecular Function GO:0043015 gamma-tubulin binding
Molecular Function GO:0008017 microtubule binding
Biological Process GO:0031122 cytoplasmic microtubule organization
Biological Process GO:0051321 meiotic cell cycle
Biological Process GO:0007020 microtubule nucleation
Biological Process GO:0000278 mitotic cell cycle
Biological Process GO:0051225 spindle assembly

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.