Overview
| Uniprot ID | Q96RU3 |
|---|
| Protein Name | Formin-binding protein 1 |
|---|
| Gene Name | FNBP1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 467 |
EVSQNIEKLRVETQK |
Function
May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL
Protein Sequence
10
MSWGTELWDQ
20
FDNLEKHTQW
30
GIDILEKYIK
40
FVKERTEIEL
50
SYAKQLRNLS
60
KKYQPKKNSK
70
EEEEYKYTSC
80
KAFISNLNEM
90
NDYAGQHEVI
100
SENMASQIIV
110
DLARYVQELK
120
QERKSNFHDG
130
RKAQQHIETC
140
WKQLESSKRR
150
FERDCKEADR
160
AQQYFEKMDA
170
DINVTKADVE
180
KARQQAQIRH
190
QMAEDSKADY
200
SSILQKFNHE
210
QHEYYHTHIP
220
NIFQKIQEME
230
ERRIVRMGES
240
MKTYAEVDRQ
250
VIPIIGKCLD
260
GIVKAAESID
270
QKNDSQLVIE
280
AYKSGFEPPG
290
DIEFEDYTQP
300
MKRTVSDNSL
310
SNSRGEGKPD
320
LKFGGKSKGK
330
LWPFIKKNKL
340
MSLLTSPHQP
350
PPPPPASASP
360
SAVPNGPQSP
370
KQQKEPLSHR
380
FNEFMTSKPK
390
IHCFRSLKRG
400
LSLKLGATPE
410
DFSNLPPEQR
420
RKKLQQKVDE
430
LNKEIQKEMD
440
QRDAITKMKD
450
VYLKNPQMGD
460
PASLDHKLAE
470
VSQNIEKLRV
480
ETQKFEAWLA
490
EVEGRLPARS
500
EQARRQSGLY
510
DSQNPPTVNN
520
CAQDRESPDG
530
SYTEEQSQES
540
EMKVLATDFD
550
DEFDDEEPLP
560
AIGTCKALYT
570
FEGQNEGTIS
580
VVEGETLYVI
590
EEDKGDGWTR
600
IRRNEDEEGY
610
VPTSYVEVCL
DKNAKDS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005938 |
cell cortex |
| Cellular Component |
GO:0005905 |
clathrin-coated pit |
| Cellular Component |
GO:0031410 |
cytoplasmic vesicle |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005764 |
lysosome |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0008289 |
lipid binding |
| Biological Process |
GO:0006897 |
endocytosis |
| Biological Process |
GO:0007165 |
signal transduction |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.