Search Results

Overview

Uniprot IDQ96S55
Protein NameATPase WRNIP1
Gene NameWRNIP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
464 SRKMFCKKSGQSYSP
627 NAPTRLMKDLGYGKG
633 MKDLGYGKGYKYNPM
70 GPSPPGAKRRRLSES

Function

Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Also plays a role in the innate immune defense against viruses. Stabilizes the RIGI dsRNA interaction and promotes RIGI 'Lys-63'-linked polyubiquitination. In turn, RIGI transmits the signal through mitochondrial MAVS

Protein Sequence

10 MEVSGPEDDP 20 FLSQLHQVQC 30 PVCQQMMPAA 40 HINSHLDRCL 50 LLHPAGHAEP 60 AAGSHRAGER 70 AKGPSPPGAK 80 RRRLSESSAL 90 KQPATPTAAE 100 SSEGEGEEGD 110 DGGETESRES 120 YDAPPTPSGA 130 RLIPDFPVAR 140 SSSPGRKGSG 150 KRPAAAAAAG 160 SASPRSWDEA 170 EAQEEEEAVG 180 DGDGDGDADA 190 DGEDDPGHWD 200 ADAAEAATAF 210 GASGGGRPHP 220 RALAAEEIRQ 230 MLQGKPLADT 240 MRPDTLQDYF 250 GQSKAVGQDT 260 LLRSLLETNE 270 IPSLILWGPP 280 GCGKTTLAHI 290 IASNSKKHSI 300 RFVTLSATNA 310 KTNDVRDVIK 320 QAQNEKSFFK 330 RKTILFIDEI 340 HRFNKSQQDT 350 FLPHVECGTI 360 TLIGATTENP 370 SFQVNAALLS 380 RCRVIVLEKL 390 PVEAMVTILM 400 RAINSLGIHV 410 LDSSRPTDPL 420 SHSSNSSSEP 430 AMFIEDKAVD 440 TLAYLSDGDA 450 RAGLNGLQLA 460 VLARLSSRKM 470 FCKKSGQSYS 480 PSRVLITEND 490 VKEGLQRSHI 500 LYDRAGEEHY 510 NCISALHKSM 520 RGSDQNASLY 530 WLARMLEGGE 540 DPLYVARRLV 550 RFASEDIGLA 560 DPSALTQAVA 570 AYQGCHFIGM 580 PECEVLLAQC 590 VVYFARAPKS 600 IEVYSAYNNV 610 KACLRNHQGP 620 LPPVPLHLRN 630 APTRLMKDLG 640 YGKGYKYNPM 650 YSEPVDQEYL 660 PEELRGVDFF KQRRC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0008047 enzyme activator activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0017116 single-stranded DNA helicase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0000731 DNA synthesis involved in DNA repair
Biological Process GO:0006261 DNA-templated DNA replication
Biological Process GO:0045087 innate immune response
Biological Process GO:0030174 regulation of DNA-templated DNA replication initiation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.