Overview
| Uniprot ID | Q96S66 |
|---|
| Protein Name | Chloride channel CLIC-like protein 1 |
|---|
| Gene Name | CLCC1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 110 |
KILIEAGKLGLPDEN |
Function
Anion-selective channel with Ca(2+)-dependent and voltage-independent gating. Permeable to small monovalent anions with selectivity for bromide > chloride > nitrate > fluoride (By similarity). Operates in the endoplasmic reticulum (ER) membrane where it mediates chloride efflux to compensate for the loss of positive charges from the ER lumen upon Ca(2+) release. Contributes to the maintenance of ER Ca(2+) pools and activation of unfolded protein response to prevent accumulation of misfolded proteins in the ER lumen. Particularly involved in ER homeostasis mechanisms underlying motor neurons and retinal photoreceptors survival (By similarity) (PubMed:25698737, PubMed:30157172, PubMed:37142673)
Protein Sequence
10
MLCSLLLCEC
20
LLLVAGYAHD
30
DDWIDPTDML
40
NYDAASGTMR
50
KSQAKYGISG
60
EKDVSPDLSC
70
ADEISECYHK
80
LDSLTYKIDE
90
CEKKKREDYE
100
SQSNPVFRRY
110
LNKILIEAGK
120
LGLPDENKGD
130
MHYDAEIILK
140
RETLLEIQKF
150
LNGEDWKPGA
160
LDDALSDILI
170
NFKFHDFETW
180
KWRFEDSFGV
190
DPYNVLMVLL
200
CLLCIVVLVA
210
TELWTYVRWY
220
TQLRRVLIIS
230
FLFSLGWNWM
240
YLYKLAFAQH
250
QAEVAKMEPL
260
NNVCAKKMDW
270
TGSIWEWFRS
280
SWTYKDDPCQ
290
KYYELLLVNP
300
IWLVPPTKAL
310
AVTFTTFVTE
320
PLKHIGKGTG
330
EFIKALMKEI
340
PALLHLPVLI
350
IMALAILSFC
360
YGAGKSVHVL
370
RHIGGPESEP
380
PQALRPRDRR
390
RQEEIDYRPD
400
GGAGDADFHY
410
RGQMGPTEQG
420
PYAKTYEGRR
430
EILRERDVDL
440
RFQTGNKSPE
450
VLRAFDVPDA
460
EAREHPTVVP
470
SHKSPVLDTK
480
PKETGGILGE
490
GTPKESSTES
500
SQSAKPVSGQ
510
DTSGNTEGSP
520
AAEKAQLKSE
530
AAGSPDQGST
540
YSPARGVAGP
550
RGQDPVSSPC
G
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0034707 |
chloride channel complex |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0044233 |
mitochondria-associated endoplasmic reticulum membrane contact site |
| Molecular Function |
GO:0005254 |
chloride channel activity |
| Biological Process |
GO:0032469 |
endoplasmic reticulum calcium ion homeostasis |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.