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Overview

Uniprot IDQ96ST2
Protein NameProtein IWS1 homolog
Gene NameIWS1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
767 KDYVVRPKWNVEMES
782 SRFQATSKKGISRLD

Function

Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription

Protein Sequence

10 MDSEYYSGDQ 20 SDDGGATPVQ 30 DERDSGSDGE 40 DDVNEQHSGS 50 DTGSVERHSE 60 NETSDREDGL 70 PKGHHVTDSE 80 NDEPLNLNAS 90 DSESEELHRQ 100 KDSDSESEER 110 AEPPASDSEN 120 EDVNQHGSDS 130 ESEETRKLPG 140 SDSENEELLN 150 GHASDSENED 160 VGKHPASDSE 170 IEELQKSPAS 180 DSETEDALKP 190 QISDSESEEP 200 PRHQASDSEN 210 EEPPKPRMSD 220 SESEELPKPQ 230 VSDSESEEPP 240 RHQASDSENE 250 ELPKPRISDS 260 ESEDPPRHQA 270 SDSENEELPK 280 PRISDSESED 290 PPRNQASDSE 300 NEELPKPRVS 310 DSESEGPQKG 320 PASDSETEDA 330 SRHKQKPESD 340 DDSDRENKGE 350 DTEMQNDSFH 360 SDSHMDRKKF 370 HSSDSEEEEH 380 KKQKMDSDED 390 EKEGEEEKVA 400 KRKAAVLSDS 410 EDEEKASAKK 420 SRVVSDADDS 430 DSDAVSDKSG 440 KREKTIASDS 450 EEEAGKELSD 460 KKNEEKDLFG 470 SDSESGNEEE 480 NLIADIFGES 490 GDEEEEEFTG 500 FNQEDLEEEK 510 GETQVKEAED 520 SDSDDNIKRG 530 KHMDFLSDFE 540 MMLQRKKSMS 550 GKRRRNRDGG 560 TFISDADDVV 570 SAMIVKMNEA 580 AEEDRQLNNQ 590 KKPALKKLTL 600 LPAVVMHLKK 610 QDLKETFIDS 620 GVMSAIKEWL 630 SPLPDRSLPA 640 LKIREELLKI 650 LQELPSVSQE 660 TLKHSGIGRA 670 VMYLYKHPKE 680 SRSNKDMAGK 690 LINEWSRPIF 700 GLTSNYKGMT 710 REEREQRDLE 720 QMPQRRRMNS 730 TGGQTPRRDL 740 EKVLTGEEKA 750 LRPGDPGFCA 760 RARVPMPSNK 770 DYVVRPKWNV 780 EMESSRFQAT 790 SKKGISRLDK 800 QMRKFTDIRK 810 KSRSAHAVKI SIEGNKMPL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0006397 mRNA processing
Biological Process GO:0016973 poly(A)+ mRNA export from nucleus
Biological Process GO:0010793 regulation of mRNA export from nucleus
Biological Process GO:0050684 regulation of mRNA processing
Biological Process GO:0008380 RNA splicing
Biological Process GO:0140673 transcription elongation-coupled chromatin remodeling

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.