Search Results

Overview

Uniprot IDQ96T58
Protein NameMsx2-interacting protein
Gene NameSPEN
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1149 ERKSGQEKSHSVNTE
1179 QMEQSRRKQQMEMEI
1240 VDFDICTKRERNYRS
1308 TVREESLKFNPYDSS
1361 SFPNSIIKRDSLRKR
1825 PNKSKRSKTPVQAAA
1864 SPRGEAQKLLELKME
1881 KITRTASKNSAADLE
2089 NSRLAVDKSASLKNV
2094 VDKSASLKNVDAAVS
2673 NALKGPVKGSVTTLK
2959 SIVTTNKKLADPVTL
2967 LADPVTLKIETKVLQ
2971 VTLKIETKVLQPANL
3020 VSHLAAAKLDAHSPR
856 EKPRSCNKLSREKAD
898 IDHTPVEKLKAKLDN
931 PAKSDLSKLESVRMK
994 RFADSNLKAEKQKPE

Function

May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA

Protein Sequence

10 MVRETRHLWV 20 GNLPENVREE 30 KIIEHFKRYG 40 RVESVKILPK 50 RGSEGGVAAF 60 VDFVDIKSAQ 70 KAHNSVNKMG 80 DRDLRTDYNE 90 PGTIPSAARG 100 LDDTVSIASR 110 SREVSGFRGG 120 GGGPAYGPPP 130 SLHAREGRYE 140 RRLDGASDNR 150 ERAYEHSAYG 160 HHERGTGGFD 170 RTRHYDQDYY 180 RDPRERTLQH 190 GLYYASRSRS 200 PNRFDAHDPR 210 YEPRAREQFT 220 LPSVVHRDIY 230 RDDITREVRG 240 RRPERNYQHS 250 RSRSPHSSQS 260 RNQSPQRLAS 270 QASRPTRSPS 280 GSGSRSRSSS 290 SDSISSSSST 300 SSDSSDSSSS 310 SSDDSPARSV 320 QSAAVPAPTS 330 QLLSSLEKDE 340 PRKSFGIKVQ 350 NLPVRSTDTS 360 LKDGLFHEFK 370 KFGKVTSVQI 380 HGTSEERYGL 390 VFFRQQEDQE 400 KALTASKGKL 410 FFGMQIEVTA 420 WIGPETESEN 430 EFRPLDERID 440 EFHPKATRTL 450 FIGNLEKTTT 460 YHDLRNIFQR 470 FGEIVDIDIK 480 KVNGVPQYAF 490 LQYCDIASVC 500 KAIKKMDGEY 510 LGNNRLKLGF 520 GKSMPTNCVW 530 LDGLSSNVSD 540 QYLTRHFCRY 550 GPVVKVVFDR 560 LKGMALVLYN 570 EIEYAQAAVK 580 ETKGRKIGGN 590 KIKVDFANRE 600 SQLAFYHCME 610 KSGQDIRDFY 620 EMLAERREER 630 RASYDYNQDR 640 TYYESVRTPG 650 TYPEDSRRDY 660 PARGREFYSE 670 WETYQGDYYE 680 SRYYDDPREY 690 RDYRNDPYEQ 700 DIREYSYRQR 710 ERERERERFE 720 SDRDRDHERR 730 PIERSQSPVH 740 LRRPQSPGAS 750 PSQAERLPSD 760 SERRLYSRSS 770 DRSGSCSSLS 780 PPRYEKLDKS 790 RLERYTKNEK 800 TDKERTFDPE 810 RVERERRLIR 820 KEKVEKDKTD 830 KQKRKGKVHS 840 PSSQSSETDQ 850 ENEREQSPEK 860 PRSCNKLSRE 870 KADKEGIAKN 880 RLELMPCVVL 890 TRVKEKEGKV 900 IDHTPVEKLK 910 AKLDNDTVKS 920 SALDQKLQVS 930 QTEPAKSDLS 940 KLESVRMKVP 950 KEKGLSSHVE 960 VVEKEGRLKA 970 RKHLKPEQPA 980 DGVSAVDLEK 990 LEARKRRFAD 1000 SNLKAEKQKP 1010 EVKKSSPEME 1020 DARVLSKKQP 1030 DVSSREVILL 1040 REGEAERKPV 1050 RKEILKRESK 1060 KIKLDRLNTV 1070 ASPKDCQELA 1080 SISVGSGSRP 1090 SSDLQARLGE 1100 LAGESVENQE 1110 VQSKKPIPSK 1120 PQLKQLQVLD 1130 DQGPEREDVR 1140 KNYCSLRDET 1150 PERKSGQEKS 1160 HSVNTEEKIG 1170 IDIDHTQSYR 1180 KQMEQSRRKQ 1190 QMEMEIAKSE 1200 KFGSPKKDVD 1210 EYERRSLVHE 1220 VGKPPQDVTD 1230 DSPPSKKKRM 1240 DHVDFDICTK 1250 RERNYRSSRQ 1260 ISEDSERTGG 1270 SPSVRHGSFH 1280 EDEDPIGSPR 1290 LLSVKGSPKV 1300 DEKVLPYSNI 1310 TVREESLKFN 1320 PYDSSRREQM 1330 ADMAKIKLSV 1340 LNSEDELNRW 1350 DSQMKQDAGR 1360 FDVSFPNSII 1370 KRDSLRKRSV 1380 RDLEPGEVPS 1390 DSDEDGEHKS 1400 HSPRASALYE 1410 SSRLSFLLRD 1420 REDKLRERDE 1430 RLSSSLERNK 1440 FYSFALDKTI 1450 TPDTKALLER 1460 AKSLSSSREE 1470 NWSFLDWDSR 1480 FANFRNNKDK 1490 EKVDSAPRPI 1500 PSWYMKKKKI 1510 RTDSEGKMDD 1520 KKEDHKEEEQ 1530 ERQELFASRF 1540 LHSSIFEQDS 1550 KRLQHLERKE 1560 EDSDFISGRI 1570 YGKQTSEGAN 1580 STTDSIQEPV 1590 VLFHSRFMEL 1600 TRMQQKEKEK 1610 DQKPKEVEKQ 1620 EDTENHPKTP 1630 ESAPENKDSE 1640 LKTPPSVGPP 1650 SVTVVTLESA 1660 PSALEKTTGD 1670 KTVEAPLVTE 1680 EKTVEPATVS 1690 EEAKPASEPA 1700 PAPVEQLEQV 1710 DLPPGADPDK 1720 EAAMMPAGVE 1730 EGSSGDQPPY 1740 LDAKPPTPGA 1750 SFSQAESNVD 1760 PEPDSTQPLS 1770 KPAQKSEEAN 1780 EPKAEKPDAT 1790 ADAEPDANQK 1800 AEAAPESQPP 1810 ASEDLEVDPP 1820 VAAKDKKPNK 1830 SKRSKTPVQA 1840 AAVSIVEKPV 1850 TRKSERIDRE 1860 KLKRSNSPRG 1870 EAQKLLELKM 1880 EAEKITRTAS 1890 KNSAADLEHP 1900 EPSLPLSRTR 1910 RRNVRSVYAT 1920 MGDHENRSPV 1930 KEPVEQPRVT 1940 RKRLERELQE 1950 AAAVPTTPRR 1960 GRPPKTRRRA 1970 DEEEENEAKE 1980 PAETLKPPEG 1990 WRSPRSQKTA 2000 AGGGPQGKKG 2010 KNEPKVDATR 2020 PEATTEVGPQ 2030 IGVKESSMEP 2040 KAAEEEAGSE 2050 QKRDRKDAGT 2060 DKNPPETAPV 2070 EVVEKKPAPE 2080 KNSKSKRGRS 2090 RNSRLAVDKS 2100 ASLKNVDAAV 2110 SPRGAAAQAG 2120 ERESGVVAVS 2130 PEKSESPQKE 2140 DGLSSQLKSD 2150 PVDPDKEPEK 2160 EDVSASGPSP 2170 EATQLAKQME 2180 LEQAVEHIAK 2190 LAEASASAAY 2200 KADAPEGLAP 2210 EDRDKPAHQA 2220 SETELAAAIG 2230 SIINDISGEP 2240 ENFPAPPPYP 2250 GESQTDLQPP 2260 AGAQALQPSE 2270 EGMETDEAVS 2280 GILETEAATE 2290 SSRPPVNAPD 2300 PSAGPTDTKE 2310 ARGNSSETSH 2320 SVPEAKGSKE 2330 VEVTLVRKDK 2340 GRQKTTRSRR 2350 KRNTNKKVVA 2360 PVESHVPESN 2370 QAQGESPAAN 2380 EGTTVQHPEA 2390 PQEEKQSEKP 2400 HSTPPQSCTS 2410 DLSKIPSTEN 2420 SSQEISVEER 2430 TPTKASVPPD 2440 LPPPPQPAPV 2450 DEEPQARFRV 2460 HSIIESDPVT 2470 PPSDPSIPIP 2480 TLPSVTAAKL 2490 SPPVASGGIP 2500 HQSPPTKVTE 2510 WITRQEEPRA 2520 QSTPSPALPP 2530 DTKASDVDTS 2540 SSTLRKILMD 2550 PKYVSATSVT 2560 STSVTTAIAE 2570 PVSAAPCLHE 2580 APPPPVDSKK 2590 PLEEKTAPPV 2600 TNNSEIQASE 2610 VLVAADKEKV 2620 APVIAPKITS 2630 VISRMPVSID 2640 LENSQKITLA 2650 KPAPQTLTGL 2660 VSALTGLVNV 2670 SLVPVNALKG 2680 PVKGSVTTLK 2690 SLVSTPAGPV 2700 NVLKGPVNVL 2710 TGPVNVLTTP 2720 VNATVGTVNA 2730 APGTVNAAAS 2740 AVNATASAVT 2750 VTAGAVTAAS 2760 GGVTATTGTV 2770 TMAGAVIAPS 2780 TKCKQRASAN 2790 ENSRFHPGSM 2800 PVIDDRPADA 2810 GSGAGLRVNT 2820 SEGVVLLSYS 2830 GQKTEGPQRI 2840 SAKISQIPPA 2850 SAMDIEFQQS 2860 VSKSQVKPDS 2870 VTASQPPSKG 2880 PQAPAGYANV 2890 ATHSTLVLTA 2900 QTYNASPVIS 2910 SVKADRPSLE 2920 KPEPIHLSVS 2930 TPVTQGGTVK 2940 VLTQGINTPP 2950 VLVHNQLVLT 2960 PSIVTTNKKL 2970 ADPVTLKIET 2980 KVLQPANLGS 2990 TLTPHHPPAL 3000 PSKLPTEVNH 3010 VPSGPSIPAD 3020 RTVSHLAAAK 3030 LDAHSPRPSG 3040 PGPSSFPRAS 3050 HPSSTASTAL 3060 STNATVMLAA 3070 GIPVPQFISS 3080 IHPEQSVIMP 3090 PHSITQTVSL 3100 SHLSQGEVRM 3110 NTPTLPSITY 3120 SIRPEALHSP 3130 RAPLQPQQIE 3140 VRAPQRASTP 3150 QPAPAGVPAL 3160 ASQHPPEEEV 3170 HYHLPVARAT 3180 APVQSEVLVM 3190 QSEYRLHPYT 3200 VPRDVRIMVH 3210 PHVTAVSEQP 3220 RAADGVVKVP 3230 PASKAPQQPG 3240 KEAAKTPDAK 3250 AAPTPTPAPV 3260 PVPVPLPAPA 3270 PAPHGEARIL 3280 TVTPSNQLQG 3290 LPLTPPVVVT 3300 HGVQIVHSSG 3310 ELFQEYRYGD 3320 IRTYHPPAQL 3330 THTQFPAASS 3340 VGLPSRTKTA 3350 AQGPPPEGEP 3360 LQPPQPVQST 3370 QPAQPAPPCP 3380 PSQLGQPGQP 3390 PSSKMPQVSQ 3400 EAKGTQTGVE 3410 QPRLPAGPAN 3420 RPPEPHTQVQ 3430 RAQAETGPTS 3440 FPSPVSVSMK 3450 PDLPVSLPTQ 3460 TAPKQPLFVP 3470 TTSGPSTPPG 3480 LVLPHTEFQP 3490 APKQDSSPHL 3500 TSQRPVDMVQ 3510 LLKKYPIVWQ 3520 GLLALKNDTA 3530 AVQLHFVSGN 3540 NVLAHRSLPL 3550 SEGGPPLRIA 3560 QRMRLEATQL 3570 EGVARRMTVE 3580 TDYCLLLALP 3590 CGRDQEDVVS 3600 QTESLKAAFI 3610 TYLQAKQAAG 3620 IINVPNPGSN 3630 QPAYVLQIFP 3640 PCEFSESHLS 3650 RLAPDLLASI 3660 SNISPHLMIV IASV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0017053 transcription repressor complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II
Biological Process GO:0007219 Notch signaling pathway
Biological Process GO:0050769 positive regulation of neurogenesis
Biological Process GO:0060816 random inactivation of X chromosome
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0031048 regulatory ncRNA-mediated heterochromatin formation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.