Search Results
Overview
| Uniprot ID | Q99020 |
|---|---|
| Protein Name | Heterogeneous nuclear ribonucleoprotein A/B |
| Gene Name | Hnrnpab |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 271 | QGSTNYGKSQRRGGH |
Function
Transcriptional repressor. Binds to CArG box motifs, single-stranded and double-stranded DNA, and RNA. It may be that repression by CBF-A is a result of competitive binding of CBF, a putative positive factor, and CBF-A to the same or overlapping motifs around the CArG boxes
Protein Sequence
10
MSDAAEEQPM
20
ETTGATENGH
30
EAAPEGEAPV
40
EPSAAAAAPA
50
ASAGSGGGTT
60
TAPSGNQNGA
70
EGDQINASKN
80
EEDAGKMFVG
90
GLSWDTSKKD
100
LKDYFTKFGE
110
VVDCTIKMDP
120
NTGRSRGFGF
130
ILFKDSSSVE
140
KVLDQKEHRL
150
DGRVIDPKKA
160
MAMKKDPVKK
170
IFVGGLNPEA
180
TEEKIREYFG
190
QFGEIEAIEL
200
PIDPKLNKRR
210
GFVFITFKEE
220
DPVKKVLEKK
230
FHTVSGSKCE
240
IKVAQPKEVY
250
QQQQYGSGGR
260
GNRNRGNRGS
270
GGGQGSTNYG
280
KSQRRGGHQN
NYKPY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0071598 | neuronal ribonucleoprotein granule |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0099523 | presynaptic cytosol |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Cellular Component | GO:0090575 | RNA polymerase II transcription regulator complex |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Biological Process | GO:0141166 | chromosomal 5-methylcytosine DNA demethylation pathway |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0001837 | epithelial to mesenchymal transition |
| Biological Process | GO:0016556 | mRNA modification |
| Biological Process | GO:2000623 | negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0060341 | regulation of cellular localization |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:1904580 | regulation of intracellular mRNA localization |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.