Search Results
Overview
| Uniprot ID | Q99426 |
|---|---|
| Protein Name | Tubulin-folding cofactor B |
| Gene Name | TBCB |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | EDVSRVEKYTISQEA |
| 153 | AQRLAEEKAQASSIP |
Function
Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0035371 | microtubule plus-end |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0043014 | alpha-tubulin binding |
| Molecular Function | GO:0051010 | microtubule plus-end binding |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0031122 | cytoplasmic microtubule organization |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0007023 | post-chaperonin tubulin folding pathway |
| Biological Process | GO:0007021 | tubulin complex assembly |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.
[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.