Search Results
Overview
| Uniprot ID | Q99471 |
|---|---|
| Protein Name | Prefoldin subunit 5 |
| Gene Name | PFDN5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 106 | AKDFFKRKIDFLTKQ |
Function
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC
Protein Sequence
10
MAQSINITEL
20
NLPQLEMLKN
30
QLDQEVEFLS
40
TSIAQLKVVQ
50
TKYVEAKDCL
60
NVLNKSNEGK
70
ELLVPLTSSM
80
YVPGKLHDVE
90
HVLIDVGTGY
100
YVEKTAEDAK
110
DFFKRKIDFL
120
TKQMEKIQPA
130
LQEKHAMKQA
140
VMEMMSQKIQ
150
QLTALGAAQA
TAKA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0016272 | prefoldin complex |
| Molecular Function | GO:0001540 | amyloid-beta binding |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:1905907 | negative regulation of amyloid fibril formation |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:1990113 | RNA polymerase I assembly |
| Biological Process | GO:1990114 | RNA polymerase II core complex assembly |
| Biological Process | GO:1990115 | RNA polymerase III assembly |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.