Search Results
Overview
| Uniprot ID | Q99489 |
|---|---|
| Protein Name | D-aspartate oxidase |
| Gene Name | DDO |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 239 | TLGGTRQKGDWNLSP |
Function
Selectively catalyzes the oxidative deamination of acidic amino acids (PubMed:1991137, PubMed:20603179, PubMed:23391306, PubMed:25747990, PubMed:28393897, PubMed:28560262, PubMed:28629864, PubMed:29292239, PubMed:31914658, PubMed:32553892, PubMed:9163533). Suppresses the level of D-aspartate in the brain, an amino acid that can act as an agonist for glutamate receptors (PubMed:28560262). Protects the organism from the toxicity of D-amino acids (By similarity). May also function in the intestine (By similarity)
Protein Sequence
10
MDTARIAVVG
20
AGVVGLSTAV
30
CISKLVPRCS
40
VTIISDKFTP
50
DTTSDVAAGM
60
LIPHTYPDTP
70
IHTQKQWFRE
80
TFNHLFAIAN
90
SAEAGDAGVH
100
LVSGWQIFQS
110
TPTEEVPFWA
120
DVVLGFRKMT
130
EAELKKFPQY
140
VFGQAFTTLK
150
CECPAYLPWL
160
EKRIKGSGGW
170
TLTRRIEDLW
180
ELHPSFDIVV
190
NCSGLGSRQL
200
AGDSKIFPVR
210
GQVLQVQAPW
220
VEHFIRDGSG
230
LTYIYPGTSH
240
VTLGGTRQKG
250
DWNLSPDAEN
260
SREILSRCCA
270
LEPSLHGACN
280
IREKVGLRPY
290
RPGVRLQTEL
300
LARDGQRLPV
310
VHHYGHGSGG
320
ISVHWGTALE
330
AARLVSECVH
340
ALRTPIPKSN
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005782 | peroxisomal matrix |
| Cellular Component | GO:0005777 | peroxisome |
| Molecular Function | GO:0008445 | D-aspartate oxidase activity |
| Molecular Function | GO:0047821 | D-glutamate oxidase activity |
| Molecular Function | GO:0071949 | FAD binding |
| Biological Process | GO:0006531 | aspartate metabolic process |
| Biological Process | GO:0019478 | D-amino acid catabolic process |
| Biological Process | GO:0170035 | L-amino acid catabolic process |
| Biological Process | GO:0006533 | L-aspartate catabolic process |
| Biological Process | GO:0050877 | nervous system process |
| Biological Process | GO:0170040 | proteinogenic amino acid catabolic process |
| Biological Process | GO:0010646 | regulation of cell communication |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.