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Overview

Uniprot IDQ99536
Protein NameNADPH-dependent quinone oxidoreductase VAT1
Gene NameVAT1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
225 FGTASASKHEALKEN
255 EIKKISPKGVDIVMD
295 ANLLTGPKRNLMALA
372 EKVADAMKQMQEKKN
382 QEKKNVGKVLLVPGP

Function

Multifunctional protein with enzymatic and transport activities (PubMed:17105775, PubMed:26394711, PubMed:32005660, PubMed:33483563). Probable NADPH-dependent quinone oxidoreductase which physiological substrates and function are unclear (PubMed:33483563). Alternatively, has also been suggested to mediate the transfer of negatively charged phospholipids including phosphatidic acid (PA), phosphatidylserine (PS) and phosphatidylglycerol (PG) between endoplasmic reticulum and mitochondrial membranes (PubMed:26394711, PubMed:32005660). Could regulate mitochondrial fusion through its interaction with mitofusins (PubMed:17105775)

Protein Sequence

10 MSDEREVAEA 20 ATGEDASSPP 30 PKTEAASDPQ 40 HPAASEGAAA 50 AAASPPLLRC 60 LVLTGFGGYD 70 KVKLQSRPAA 80 PPAPGPGQLT 90 LRLRACGLNF 100 ADLMARQGLY 110 DRLPPLPVTP 120 GMEGAGVVIA 130 VGEGVSDRKA 140 GDRVMVLNRS 150 GMWQEEVTVP 160 SVQTFLIPEA 170 MTFEEAAALL 180 VNYITAYMVL 190 FDFGNLQPGH 200 SVLVHMAAGG 210 VGMAAVQLCR 220 TVENVTVFGT 230 ASASKHEALK 240 ENGVTHPIDY 250 HTTDYVDEIK 260 KISPKGVDIV 270 MDPLGGSDTA 280 KGYNLLKPMG 290 KVVTYGMANL 300 LTGPKRNLMA 310 LARTWWNQFS 320 VTALQLLQAN 330 RAVCGFHLGY 340 LDGEVELVSG 350 VVARLLALYN 360 QGHIKPHIDS 370 VWPFEKVADA 380 MKQMQEKKNV 390 GKVLLVPGPE KEN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035578 azurophil granule lumen
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005741 mitochondrial outer membrane
Molecular Function GO:0008753 NADPH dehydrogenase (quinone) activity
Molecular Function GO:0120014 phospholipid transfer activity
Molecular Function GO:0003960 quinone reductase (NADPH) activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0120010 intermembrane phospholipid transfer
Biological Process GO:0010637 negative regulation of mitochondrial fusion

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.