Search Results

Overview

Uniprot IDQ99547
Protein NameM-phase phosphoprotein 6
Gene NameMPHOSPH6
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
11 ERKTRLSKNLLRMKF
127 TLVGTIGKKFARKRD
128 LVGTIGKKFARKRDH
132 IGKKFARKRDHANYE
150 NGDITPIKAKKMFLK
152 DITPIKAKKMFLKPQ
153 ITPIKAKKMFLKPQD

Function

RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D

Protein Sequence

10 MAAERKTRLS 20 KNLLRMKFMQ 30 RGLDSETKKQ 40 LEEEEKKIIS 50 EEHWYLDLPE 60 LKEKESFIIE 70 EQSFLLCEDL 80 LYGRMSFRGF 90 NPEVEKLMLQ 100 MNAKHKAEEV 110 EDETVELDVS 120 DEEMARRYET 130 LVGTIGKKFA 140 RKRDHANYEE 150 DENGDITPIK 160 AKKMFLKPQD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0000178 exosome (RNase complex)
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003723 RNA binding
Biological Process GO:0000460 maturation of 5.8S rRNA

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[5] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[6] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.