Search Results
Overview
| Uniprot ID | Q99551 |
|---|---|
| Protein Name | Transcription termination factor 1, mitochondrial |
| Gene Name | MTERF1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 13 | LGQTSISKGLNYLTI |
Function
Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand
Protein Sequence
10
MQSLSLGQTS
20
ISKGLNYLTI
30
MAPGNLWHMR
40
NNFLFGSRCW
50
MTRFSAENIF
60
KSVSFRLFGV
70
KCHNTDSEPL
80
KNEDLLKNLL
90
TMGVDIDMAR
100
KRQPGVFHRM
110
ITNEQDLKMF
120
LLSKGASKEV
130
IASIISRYPR
140
AITRTPENLS
150
KRWDLWRKIV
160
TSDLEIVNIL
170
ERSPESFFRS
180
NNNLNLENNI
190
KFLYSVGLTR
200
KCLCRLLTNA
210
PRTFSNSLDL
220
NKQMVEFLQA
230
AGLSLGHNDP
240
ADFVRKIIFK
250
NPFILIQSTK
260
RVKANIEFLR
270
STFNLNSEEL
280
LVLICGPGAE
290
ILDLSNDYAR
300
RSYANIKEKL
310
FSLGCTEEEV
320
QKFVLSYPDV
330
IFLAEKKFND
340
KIDCLMEENI
350
SISQIIENPR
360
VLDSSISTLK
370
SRIKELVNAG
380
CNLSTLNITL
390
LSWSKKRYEA
KLKKLSRFA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0042645 | mitochondrial nucleoid |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Molecular Function | GO:0003676 | nucleic acid binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0032392 | DNA geometric change |
| Biological Process | GO:0006353 | DNA-templated transcription termination |
| Biological Process | GO:0006393 | termination of mitochondrial transcription |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.