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Overview

Uniprot IDQ99571
Protein NameP2X purinoceptor 4
Gene NameP2RX4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
215 NITTTYLKSCIYDAK

Function

ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:9016352). CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4 (By similarity). Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology (PubMed:35165166). Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Also participates in basal T-cell activity without TCR/CD3 stimulation (By similarity). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (PubMed:35165166). Upon activation, drives microglia motility via the PI3K/Akt pathway (By similarity). Could also function as an ATP-gated cation channel of lysosomal membranes (By similarity)

Protein Sequence

10 MAGCCAALAA 20 FLFEYDTPRI 30 VLIRSRKVGL 40 MNRAVQLLIL 50 AYVIGWVFVW 60 EKGYQETDSV 70 VSSVTTKVKG 80 VAVTNTSKLG 90 FRIWDVADYV 100 IPAQEENSLF 110 VMTNVILTMN 120 QTQGLCPEIP 130 DATTVCKSDA 140 SCTAGSAGTH 150 SNGVSTGRCV 160 AFNGSVKTCE 170 VAAWCPVEDD 180 THVPQPAFLK 190 AAENFTLLVK 200 NNIWYPKFNF 210 SKRNILPNIT 220 TTYLKSCIYD 230 AKTDPFCPIF 240 RLGKIVENAG 250 HSFQDMAVEG 260 GIMGIQVNWD 270 CNLDRAASLC 280 LPRYSFRRLD 290 TRDVEHNVSP 300 GYNFRFAKYY 310 RDLAGNEQRT 320 LIKAYGIRFD 330 IIVFGKAGKF 340 DIIPTMINIG 350 SGLALLGMAT 360 VLCDIIVLYC 370 MKKRLYYREK 380 KYKYVEDYEQ GLASELDQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0044297 cell body
Biological Process GO:0071294 cellular response to zinc ion
Biological Process GO:0042118 endothelial cell activation
Biological Process GO:0051899 membrane depolarization
Biological Process GO:0034220 monoatomic ion transmembrane transport
Biological Process GO:0010614 negative regulation of cardiac muscle hypertrophy
Biological Process GO:0043536 positive regulation of blood vessel endothelial cell migration
Biological Process GO:0051928 positive regulation of calcium ion transport
Biological Process GO:0010524 positive regulation of calcium ion transport into cytosol
Biological Process GO:0050850 positive regulation of calcium-mediated signaling
Biological Process GO:2001028 positive regulation of endothelial cell chemotaxis
Biological Process GO:1904141 positive regulation of microglial cell migration
Biological Process GO:0045429 positive regulation of nitric oxide biosynthetic process
Biological Process GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Process GO:0032308 positive regulation of prostaglandin secretion
Biological Process GO:0035590 purinergic nucleotide receptor signaling pathway
Biological Process GO:0008217 regulation of blood pressure
Biological Process GO:0055117 regulation of cardiac muscle contraction
Biological Process GO:0050920 regulation of chemotaxis
Biological Process GO:0002028 regulation of sodium ion transport
Biological Process GO:0055119 relaxation of cardiac muscle
Biological Process GO:0033198 response to ATP
Biological Process GO:0048678 response to axon injury
Biological Process GO:0034405 response to fluid shear stress
Biological Process GO:0002931 response to ischemia
Biological Process GO:0019233 sensory perception of pain
Biological Process GO:0050975 sensory perception of touch
Biological Process GO:0007165 signal transduction
Biological Process GO:0001894 tissue homeostasis
Cellular Component GO:0030054 cell junction
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0016020 membrane
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098794 postsynapse
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0045296 cadherin binding
Molecular Function GO:0005507 copper ion binding
Molecular Function GO:0004931 extracellularly ATP-gated monoatomic cation channel activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0099604 ligand-gated calcium channel activity
Molecular Function GO:0001614 purinergic nucleotide receptor activity
Molecular Function GO:0005102 signaling receptor binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0097190 apoptotic signaling pathway
Biological Process GO:0048266 behavioral response to pain
Biological Process GO:0070588 calcium ion transmembrane transport
Biological Process GO:0019722 calcium-mediated signaling
Biological Process GO:0071318 cellular response to ATP

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.