Search Results

Overview

Uniprot IDQ99575
Protein NameRibonucleases P/MRP protein subunit POP1
Gene NamePOP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
379 QTELPDEKIGKKRKR
382 LPDEKIGKKRKRKDD
397 GENAKPIKKIIGDGT
398 ENAKPIKKIIGDGTR
750 VPCAPMPKKTHQPSD
751 PCAPMPKKTHQPSDE
88 FRKKGGWKAGPEGTS

Function

Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:8918471). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465)

Protein Sequence

10 MSNAKERKHA 20 KKMRNQPTNV 30 TLSSGFVADR 40 GVKHHSGGEK 50 PFQAQKQEPH 60 PGTSRQRQTR 70 VNPHSLPDPE 80 VNEQSSSKGM 90 FRKKGGWKAG 100 PEGTSQEIPK 110 YITASTFAQA 120 RAAEISAMLK 130 AVTQKSSNSL 140 VFQTLPRHMR 150 RRAMSHNVKR 160 LPRRLQEIAQ 170 KEAEKAVHQK 180 KEHSKNKCHK 190 ARRCHMNRTL 200 EFNRRQKKNI 210 WLETHIWHAK 220 RFHMVKKWGY 230 CLGERPTVKS 240 HRACYRAMTN 250 RCLLQDLSYY 260 CCLELKGKEE 270 EILKALSGMC 280 NIDTGLTFAA 290 VHCLSGKRQG 300 SLVLYRVNKY 310 PREMLGPVTF 320 IWKSQRTPGD 330 PSESRQLWIW 340 LHPTLKQDIL 350 EEIKAACQCV 360 EPIKSAVCIA 370 DPLPTPSQEK 380 SQTELPDEKI 390 GKKRKRKDDG 400 ENAKPIKKII 410 GDGTRDPCLP 420 YSWISPTTGI 430 IISDLTMEMN 440 RFRLIGPLSH 450 SILTEAIKAA 460 SVHTVGEDTE 470 ETPHRWWIET 480 CKKPDSVSLH 490 CRQEAIFELL 500 GGITSPAEIP 510 AGTILGLTVG 520 DPRINLPQKK 530 SKALPNPEKC 540 QDNEKVRQLL 550 LEGVPVECTH 560 SFIWNQDICK 570 SVTENKISDQ 580 DLNRMRSELL 590 VPGSQLILGP 600 HESKIPILLI 610 QQPGKVTGED 620 RLGWGSGWDV 630 LLPKGWGMAF 640 WIPFIYRGVR 650 VGGLKESAVH 660 SQYKRSPNVP 670 GDFPDCPAGM 680 LFAEEQAKNL 690 LEKYKRRPPA 700 KRPNYVKLGT 710 LAPFCCPWEQ 720 LTQDWESRVQ 730 AYEEPSVASS 740 PNGKESDLRR 750 SEVPCAPMPK 760 KTHQPSDEVG 770 TSIEHPREAE 780 EVMDAGCQES 790 AGPERITDQE 800 ASENHVAATG 810 SHLCVLRSRK 820 LLKQLSAWCG 830 PSSEDSRGGR 840 RAPGRGQQGL 850 TREACLSILG 860 HFPRALVWVS 870 LSLLSKGSPE 880 PHTMICVPAK 890 EDFLQLHEDW 900 HYCGPQESKH 910 SDPFRSKILK 920 QKEKKKREKR 930 QKPGRASSDG 940 PAGEEPVAGQ 950 EALTLGLWSG 960 PLPRVTLHCS 970 RTLLGFVTQG 980 DFSMAVGCGE 990 ALGFVSLTGL 1000 LDMLSSQPAA 1010 QRGLVLLRPP 1020 ASLQYRFARI AIEV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0030681 multimeric ribonuclease P complex
Cellular Component GO:0005655 nucleolar ribonuclease P complex
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0000172 ribonuclease MRP complex
Molecular Function GO:0033204 ribonuclease P RNA binding
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006396 RNA processing
Biological Process GO:0001682 tRNA 5'-leader removal
Biological Process GO:0016078 tRNA decay
Biological Process GO:0008033 tRNA processing

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.