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Overview

Uniprot ID	Q99584
Protein Name	Protein S100-A13
Gene Name	S100A13
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
30	FARQEGRKDSLSVNE

Function

Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine (By similarity)

Protein Sequence

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0048471	perinuclear region of cytoplasm
Molecular Function	GO:0005509	calcium ion binding
Molecular Function	GO:0048306	calcium-dependent protein binding
Molecular Function	GO:0005507	copper ion binding
Molecular Function	GO:0017134	fibroblast growth factor binding
Molecular Function	GO:0008289	lipid binding
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0050786	RAGE receptor binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0043303	mast cell degranulation
Biological Process	GO:0043123	positive regulation of canonical NF-kappaB signal transduction
Biological Process	GO:0001819	positive regulation of cytokine production
Biological Process	GO:0032730	positive regulation of interleukin-1 alpha production
Biological Process	GO:0015031	protein transport

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.