Search Results

Overview

Uniprot IDQ99590
Protein NameProtein SCAF11
Gene NameSCAF11
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1000 NENTRKEKNDIHLDA
1090 YRSSFAYKDQNENRW
1101 ENRWQNRKPLSGNSN
1354 KASNAAVKLAESKVS
1420 VDKVCHSKSGEVNST
676 KNNLLNTKLEKSLEE
950 SRCRTKSKSSSFGRI

Function

Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly

Protein Sequence

10 MKKKTVCTLN 20 MGDKKYEDME 30 GEENGDNTIS 40 TGLLYSEADR 50 CPICLNCLLE 60 KEVGFPESCN 70 HVFCMTCILK 80 WAETLASCPI 90 DRKPFQAVFK 100 FSALEGYVKV 110 QVKKQLRETK 120 DKKNENSFEK 130 QVSCHENSKS 140 CIRRKAIVRE 150 DLLSAKVCDL 160 KWIHRNSLYS 170 ETGGKKNAAI 180 KINKPQRSNW 190 STNQCFRNFF 200 SNMFSSVSHS 210 GESSFTYRAY 220 CTEFIEASEI 230 SALIRQKRHE 240 LELSWFPDTL 250 PGIGRIGFIP 260 WNVETEVLPL 270 ISSVLPRTIF 280 PTSTISFEHF 290 GTSCKGYALA 300 HTQEGEEKKQ 310 TSGTSNTRGS 320 RRKPAMTTPT 330 RRSTRNTRAE 340 TASQSQRSPI 350 SDNSGCDAPG 360 NSNPSLSVPS 370 SAESEKQTRQ 380 APKRKSVRRG 390 RKPPLLKKKL 400 RSSVAAPEKS 410 SSNDSVDEET 420 AESDTSPVLE 430 KEHQPDVDSS 440 NICTVQTHVE 450 NQSANCLKSC 460 NEQIEESEKH 470 TANYDTEERV 480 GSSSSESCAQ 490 DLPVLVGEEG 500 EVKKLENTGI 510 EANVLCLESE 520 ISENILEKGG 530 DPLEKQDQIS 540 GLSQSEVKTD 550 VCTVHLPNDF 560 PTCLTSESKV 570 YQPVSCPLSD 580 LSENVESVVN 590 EEKITESSLV 600 EITEHKDFTL 610 KTEELIESPK 620 LESSEGEIIQ 630 TVDRQSVKSP 640 EVQLLGHVET 650 EDVEIIATCD 660 TFGNEDFNNI 670 QDSENNLLKN 680 NLLNTKLEKS 690 LEEKNESLTE 700 HPRSTELPKT 710 HIEQIQKHFS 720 EDNNEMIPME 730 CDSFCSDQNE 740 SEVEPSVNAD 750 LKQMNENSVT 760 HCSENNMPSS 770 DLADEKVETV 780 SQPSESPKDT 790 IDKTKKPRTR 800 RSRFHSPSTT 810 WSPNKDTPQE 820 KKRPQSPSPR 830 RETGKESRKS 840 QSPSPKNESA 850 RGRKKSRSQS 860 PKKDIARERR 870 QSQSRSPKRD 880 TTRESRRSES 890 LSPRRETSRE 900 NKRSQPRVKD 910 SSPGEKSRSQ 920 SRERESDRDG 930 QRRERERRTR 940 KWSRSRSHSR 950 SPSRCRTKSK 960 SSSFGRIDRD 970 SYSPRWKGRW 980 ANDGWRCPRG 990 NDRYRKNDPE 1000 KQNENTRKEK 1010 NDIHLDADDP 1020 NSADKHRNDC 1030 PNWITEKINS 1040 GPDPRTRNPE 1050 KLKESHWEEN 1060 RNENSGNSWN 1070 KNFGSGWVSN 1080 RGRGRGNRGR 1090 GTYRSSFAYK 1100 DQNENRWQNR 1110 KPLSGNSNSS 1120 GSESFKFVEQ 1130 QSYKRKSEQE 1140 FSFDTPADRS 1150 GWTSASSWAV 1160 RKTLPADVQN 1170 YYSRRGRNSS 1180 GPQSGWMKQE 1190 EETSGQDSSL 1200 KDQTNQQVDG 1210 SQLPINMMQP 1220 QMNVMQQQMN 1230 AQHQPMNIFP 1240 YPVGVHAPLM 1250 NIQRNPFNIH 1260 PQLPLHLHTG 1270 VPLMQVATPT 1280 SVSQGLPPPP 1290 PPPPPSQQVN 1300 YIASQPDGKQ 1310 LQGIPSSSHV 1320 SNNMSTPVLP 1330 APTAAPGNTG 1340 MVQGPSSGNT 1350 SSSSHSKASN 1360 AAVKLAESKV 1370 SVAVEASADS 1380 SKTDKKLQIQ 1390 EKAAQEVKLA 1400 IKPFYQNKDI 1410 TKEEYKEIVR 1420 KAVDKVCHSK 1430 SGEVNSTKVA 1440 NLVKAYVDKY 1450 KYSRKGSQKK 1460 TLEEPVSTEK NIG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0016604 nuclear body
Biological Process GO:0006397 mRNA processing
Biological Process GO:0008380 RNA splicing
Biological Process GO:0000375 RNA splicing, via transesterification reactions
Biological Process GO:0000245 spliceosomal complex assembly
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0008270 zinc ion binding

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.