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Overview

Uniprot IDQ99598
Protein NameTranslin-associated protein X
Gene NameTSNAX
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
14 SGGFRKRKHDNFPHN
27 HNQRREGKDVNSSSP
4 ****MSNKEGSGGFR

Function

Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis

Protein Sequence

10 MSNKEGSGGF 20 RKRKHDNFPH 30 NQRREGKDVN 40 SSSPVMLAFK 50 SFQQELDARH 60 DKYERLVKLS 70 RDITVESKRT 80 IFLLHRITSA 90 PDMEDILTES 100 EIKLDGVRQK 110 IFQVAQELSG 120 EDMHQFHRAI 130 TTGLQEYVEA 140 VSFQHFIKTR 150 SLISMDEINK 160 QLIFTTEDNG 170 KENKTPSSDA 180 QDKQFGTWRL 190 RVTPVDYLLG 200 VADLTGELMR 210 MCINSVGNGD 220 IDTPFEVSQF 230 LRQVYDGFSF 240 IGNTGPYEVS 250 KKLYTLKQSL 260 AKVENACYAL 270 KVRGSEIPKH 280 MLADVFSVKT 290 EMIDQEEGIS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Molecular Function GO:0031687 A2A adenosine receptor binding
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0004521 RNA endonuclease activity
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:0003697 single-stranded DNA binding
Biological Process GO:0030154 cell differentiation
Biological Process GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
Biological Process GO:0030422 siRNA processing
Biological Process GO:0007283 spermatogenesis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.